Developmental Changes in Sleep Spindle Characteristics and Sigma Power across Early Childhood
| Autor: | Monique K. LeBourgeois, Peter Achermann, Jonathan M. Lassonde, Caroline Lustenberger, Ian J. McClain, Salome Kurth |
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| Přispěvatelé: | University of Zurich, LeBourgeois, Monique K |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Article Subject 10050 Institute of Pharmacology and Toxicology 610 Medicine & health Sleep spindle Audiology Electroencephalography Non-rapid eye movement sleep lcsh:RC321-571 03 medical and health sciences 0302 clinical medicine Child Development medicine Humans Wakefulness lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Sleep Stages medicine.diagnostic_test Eye movement Brain Sleep in non-human animals Brain Waves 2728 Neurology (clinical) 030104 developmental biology Neurology 2808 Neurology Child Preschool 570 Life sciences biology Female Neurology (clinical) K-complex Psychology Sleep 030217 neurology & neurosurgery Research Article |
| Zdroj: | Neural Plasticity Neural plasticity Neural Plasticity, Vol 2016 (2016) |
| ISSN: | 1687-5443 |
| Popis: | Sleep spindles, a prominent feature of the non-rapid eye movement (NREM) sleep electroencephalogram (EEG), are linked to cognitive abilities. Early childhood is a time of rapid cognitive and neurophysiological maturation; however, little is known about developmental changes in sleep spindles. In this study, we longitudinally examined trajectories of multiple sleep spindle characteristics (i.e., spindle duration, frequency, integrated spindle amplitude, and density) and power in the sigma frequency range (10–16 Hz) across ages 2, 3, and 5 years (n=8; 3 males). At each time point, nocturnal sleep EEG was recorded in-home after 13-h of prior wakefulness. Spindle duration, integrated spindle amplitude, and sigma power increased with age across all EEG derivations (C3A2, C4A1, O2A1, and O1A2; allps < 0.05). We also found a developmental decrease in mean spindle frequency (p<0.05) but no change in spindle density with increasing age. Thus, sleep spindles increased in duration and amplitude but decreased in frequency across early childhood. Our data characterize early developmental changes in sleep spindles, which may advance understanding of thalamocortical brain connectivity and associated lifelong disease processes. These findings also provide unique insights into spindle ontogenesis in early childhood and may help identify electrophysiological features related to healthy and aberrant brain maturation. |
| Databáze: | OpenAIRE |
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