Intake of Lactobacillus plantarum HEAL9 reduces the inflammatory markers soluble fractalkine and CD163 during acute stress : a randomized, double blind, placebo-controlled study
| Autor: | Magnus Hillman, Joakim Eriksson, Maria Hedin, Gunilla Önning, Caroline Montelius, Peter Jönsson, Siv Ahrné |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Hypothalamo-Hypophyseal System
medicine.medical_specialty Chemokine Fysiologi Hydrocortisone CX3CL1 Physiology Placebo-controlled study Antigens Differentiation Myelomonocytic Pituitary-Adrenal System Receptors Cell Surface Experimental and Cognitive Psychology Inflammation Placebo law.invention 03 medical and health sciences Behavioral Neuroscience Probiotic 0302 clinical medicine Antigens CD law Internal medicine medicine Trier social stress test Humans Psychology 0501 psychology and cognitive sciences Chronic stress 050102 behavioral science & comparative psychology Saliva Psykologi biology Chemokine CX3CL1 05 social sciences HPA axis Psychosocial stress TSST Virtual reality Endocrinology biology.protein medicine.symptom Stress Psychological 030217 neurology & neurosurgery |
| Popis: | The intestine and the brain are connected via the brain-gut axis and the intestinal microbiota influences the immune activation and signaling molecules that are involved in the stress response. The aim of the study was to investigate if intake of the probiotic strain Lactiplantibacillus plantarum HEAL9 (LPHEAL9) for four weeks could counteract elevated cortisol and inflammation levels in subjects with chronic stress that are exposed to an acute stress test (Trier Social Stress Test, TSST). Seventy participants were included, and 63 participants completed the study (LPHEAL9, n = 32; placebo, n = 31). Cardiovascular reactivity and cortisol levels were affected by the TSST, but no differences between the groups were observed. Intake of LPHEAL9 did, however, result in significantly decreased plasma levels of two inflammatory markers (soluble fractalkine and CD163) compared to placebo. In conclusion, intake of LPHEAL9 for four weeks may reduce inflammatory markers coupled to acute stress in chronically stressed individuals. |
| Databáze: | OpenAIRE |
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