Low Physical Activity in Patients with Complicated Type 2 Diabetes Mellitus Is Associated with Low Muscle Mass and Low Protein Intake
| Autor: | Ilse J. M. Hagedoorn, Gozewijn D. Laverman, Niala den Braber, Cristina M. Gant, Milou M. Oosterwijk, Gerjan Navis, Miriam Marie Rosé Vollenbroek-Hutten, Stephan J. L. Bakker, Bert-Jan van Beijnum |
|---|---|
| Přispěvatelé: | Value, Affordability and Sustainability (VALUE), Groningen Kidney Center (GKC), Groningen Institute for Organ Transplantation (GIOT), Biomedical Signals and Systems, TechMed Centre |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Low protein BODY-COMPOSITION Urinary system lcsh:Medicine physical activity 030209 endocrinology & metabolism Type 2 diabetes Gastroenterology Article SARCOPENIA 03 medical and health sciences 0302 clinical medicine PEOPLE Internal medicine Diabetes mellitus STRENGTH medicine ACTIVITY PATTERNS 030212 general & internal medicine OLDER business.industry Confounding lcsh:R Type 2 Diabetes Mellitus General Medicine ADULTS medicine.disease protein intake LEAN MASS PREVALENCE accelerometer muscle mass Cohort type 2 diabetes business Body mass index |
| Zdroj: | Journal of Clinical Medicine, 9(10):3104. MDPI AG Journal of Clinical Medicine Volume 9 Issue 10 Journal of Clinical Medicine, Vol 9, Iss 3104, p 3104 (2020) Journal of Clinical Medicine, 9(10):3104. MDPI |
| ISSN: | 2077-0383 |
| Popis: | Objective: In order to promote physical activity (PA) in patients with complicated type 2 diabetes, a better understanding of daily movement is required. We (1) objectively assessed PA in patients with type 2 diabetes, and (2) studied the association between muscle mass, dietary protein intake, and PA. Methods: We performed cross-sectional analyses in all patients included in the Diabetes and Lifestyle Cohort Twente (DIALECT) between November 2016 and November 2018. Patients were divided into four groups: < 5000, 5000&ndash 6999, 7000&ndash 9999, &ge 10,000 steps/day. We studied the association between muscle mass (24 h urinary creatinine excretion rate, CER) and protein intake (by Maroni formula), and the main outcome variable PA (steps/day, Fitbit Flex device) using multivariate linear regression analyses. Results: In the 217 included patients, the median steps/day were 6118 (4115&ndash 8638). Of these patients, 48 patients (22%) took 7000&ndash 9999 steps/day, 37 patients (17%) took &ge 10,000 steps/day, and 78 patients (36%) took < 5000 steps/day. Patients with < 5000 steps/day had, in comparison to patients who took &ge 10,000 steps/day, a higher body mass index (BMI) (33 ± 6 vs. 30 ± 5 kg/m2, p = 0.009), lower CER (11.7 ± 4.8 vs. 14.8 ± 3.8 mmol/24 h, p = 0.001), and lower protein intake (0.84 ± 0.29 vs. 1.08 ± 0.22 g/kg/day, p < 0.001). Both creatinine excretion (&beta = 0.26, p < 0.001) and dietary protein intake (&beta = 0.31, p < 0.001) were strongly associated with PA, which remained unchanged after adjustment for potential confounders. Conclusions: Prevalent insufficient protein intake and low muscle mass co-exist in obese patients with low physical activity. Dedicated intervention studies are needed to study the role of sufficient protein intake and physical activity in increasing or maintaining muscle mass in patients with type 2 diabetes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|