Is Vitamin B6 Supplementation of Isoniazid Therapy Useful in Childhood Tuberculosis?
| Autor: | R Matendo, R Nkailu, L Mbala |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Male
Vitamin Pediatrics medicine.medical_specialty Tuberculosis Adolescent Antitubercular Agents Placebo-controlled study Placebo law.invention chemistry.chemical_compound Pharmacotherapy Randomized controlled trial law Isoniazid medicine Humans Single-Blind Method Prospective Studies Child Tuberculosis Pulmonary Antibacterial agent business.industry Public Health Environmental and Occupational Health Infant Pyridoxine medicine.disease Surgery Treatment Outcome Infectious Diseases chemistry Child Preschool Democratic Republic of the Congo Drug Therapy Combination Female business medicine.drug |
| Zdroj: | Tropical Doctor. 28:103-104 |
| ISSN: | 1758-1133 0049-4755 |
| DOI: | 10.1177/004947559802800218 |
| Popis: | We present the results of a prospective single blind placebo controlled study performed to establish whether vitamin B6 supplementation of isoniazid therapy is useful in childhood tuberculosis. Eighty-five children suffering from tuberculosis (TB) and admitted between 1 October 1993 and 31 March 1995 to the Hospital of IME-Kimpese (Lower Zaire) were included. All were treated with isoniazid and other antitubercular drugs and were randomized to receive either vitamin B6 supplementation or placebo. No case of neurological or neuropsychiatric disorder was observed in the two groups during the 6 months of the treatment and 3 months after the treatment. These results suggest that the vitamin B6 supplementation of isoniazid therapy is unnecessary in childhood TB. |
| Databáze: | OpenAIRE |
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