Vascular endothelial growth factor levels in serum and plasma following esophageal cancer resection--relationship to platelet count
| Autor: | Gm, Spence, An, Graham, Mulholland K, Ian McAllister, Jm, Sloan, Ma, Armstrong, Fc, Campbell, Ja, Mcguigan |
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| Rok vydání: | 2002 |
| Předmět: |
0301 basic medicine
Male Vascular Endothelial Growth Factor A Cancer Research Lymphokines Esophageal Neoplasms Platelet Count Vascular Endothelial Growth Factors Clinical Biochemistry Endothelial Growth Factors Middle Aged Pathology and Forensic Medicine Esophagectomy 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Oncology 030220 oncology & carcinogenesis Humans Intercellular Signaling Peptides and Proteins Female Aged |
| Zdroj: | Europe PubMed Central |
| ISSN: | 0393-6155 |
| Popis: | In patients with cancer circulating vascular endothelial growth factor (VEGF) may be tumor-derived and have prognostic significance. Activated platelets may also be a source of VEGF, releasing it in serum formation. Debate exists as to whether serum or plasma VEGF (S-VEGF, P-VEGF) is the most appropriate surrogate marker of tumor angiogenesis. As healing wounds produce VEGF that can spill over into the circulation, we aimed to investigate the potential confounding effects of cancer surgery on both perioperative S-VEGF and P-VEGF levels and to evaluate their relationship with platelet count. S-VEGF, P-VEGF and platelet counts were measured in 23 patients undergoing esophageal cancer resection. Samples were taken preoperatively and six weeks following surgery. Seven patients were also sampled on postoperative days 1, 5 and 10. VEGF was assayed using a commercial enzyme linked immunosorbent assay. S-VEGF and P-VEGF both rose after surgery (S-VEGF; day 5: 1017 [446–1224] pg/mL and day 10: 1231 [626–2046] pg/mL versus pre-op: 329 [189–599] pg/mL. P-VEGF; day 1: 55 [46–104] pg/mL and day 10: 58 [20–154] pg/mL versus pre-op: 23 [13–46] pg/mL), falling towards pre-operative levels by six weeks. Platelet count correlated with S-VEGF (rho=0.281; p |
| Databáze: | OpenAIRE |
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