Transcriptional Regulation of the Multiple Resistance Mechanisms in Salmonella—A Review
| Autor: | Marek Roszko, Olga Świder, Barbara Sokołowska, Edyta Juszczuk-Kubiak, Paulina Średnicka, Michał Wójcicki, Kamila J Daniluk, Monika Akimowicz |
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| Rok vydání: | 2021 |
| Předmět: |
Microbiology (medical)
Salmonella antibiotic resistance medicine.drug_class Antibiotics Review Biology medicine.disease_cause Microbiology 03 medical and health sciences Antibiotic resistance transcription regulators medicine Transcriptional regulation Immunology and Allergy Molecular Biology Pathogen 030304 developmental biology 0303 health sciences General Immunology and Microbiology 030306 microbiology biology.organism_classification Multiple drug resistance Infectious Diseases Ceftriaxone Medicine Bacteria medicine.drug |
| Zdroj: | Pathogens, Vol 10, Iss 801, p 801 (2021) Pathogens |
| ISSN: | 2076-0817 |
| DOI: | 10.3390/pathogens10070801 |
| Popis: | The widespread use of antibiotics, especially those with a broad spectrum of activity, has resulted in the development of multidrug resistance in many strains of bacteria, including Salmonella. Salmonella is among the most prevalent causes of intoxication due to the consumption of contaminated food and water. Salmonellosis caused by this pathogen is pharmacologically treated using antibiotics such as fluoroquinolones, ceftriaxone, and azithromycin. This foodborne pathogen developed several molecular mechanisms of resistance both on the level of global and local transcription modulators. The increasing rate of antibiotic resistance in Salmonella poses a significant global concern, and an improved understanding of the multidrug resistance mechanisms in Salmonella is essential for choosing the suitable antibiotic for the treatment of infections. In this review, we summarized the current knowledge of molecular mechanisms that control gene expression related to antibiotic resistance of Salmonella strains. We characterized regulators acting as transcription activators and repressors, as well as two-component signal transduction systems. We also discuss the background of the molecular mechanisms of the resistance to metals, regulators of multidrug resistance to antibiotics, global regulators of the LysR family, as well as regulators of histone-like proteins. |
| Databáze: | OpenAIRE |
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