Impact of thrombus burden on long-term clinical outcomes in patients with either anterior or non-anterior ST-segment elevation myocardial infarction
| Autor: | Menno van Gameren, Roberto Diletti, Nicolas M. Van Mieghem, Wijnand K den Dekker, Joost Daemen, Paola Scarparo, J. Wilschut, Felix Zijlstra |
|---|---|
| Přispěvatelé: | Cardiology |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Myocardial Infarction Coronary Angiography Anterior ST segment elevation Percutaneous Coronary Intervention Internal medicine medicine Humans Myocardial infarction cardiovascular diseases Thrombus Non-ST Elevated Myocardial Infarction Hematology business.industry Coronary Thrombosis Percutaneous coronary intervention Drug-Eluting Stents medicine.disease Treatment Outcome Thrombus burden Drug-eluting stent Cardiology ST Elevation Myocardial Infarction Cardiology and Cardiovascular Medicine business Mace |
| Zdroj: | Journal of Thrombosis and Thrombolysis, 54(1), 47-57. Springer Netherlands |
| ISSN: | 0929-5305 |
| Popis: | Large thrombus burden (LTB) during ST-segment elevation myocardial infarction (STEMI) could translate into worse clinical outcomes. The impact of a LTB in terms of long-term clinical outcomes on different myocardial infarct territories has not yet been fully evaluated. From April 2002 to December 2004, consecutive patients with STEMI undergoing percutaneous coronary intervention with drug eluting stent were evaluated. The study sample was stratified in two groups: anterior STEMI and non-anterior STEMI. LTB was considered as a thrombus larger than or equal to 2-vessel diameters, and small thrombus burden less than 2-vessel diameters. Major adverse cardiac events (MACE) were evaluated at 10-year and survival data were collected up to 15-year. A total of 812 patients were evaluated, 6 patients were excluded due to inadequate angiographic images, 410 (50.9%) had an anterior STEMI and 396 (49.1%) a non-anterior STEMI. Patients with LTB had higher rates of 10-year mortality (aHR 2.27, 95%CI 1.42–3.63; p = 0.001) and 10-year MACE (aHR 1.46, 95%CI 1.03–2.08; p = 0.033) in anterior STEMI, but not in non-anterior STEMI (aHR 0.78, 95%CI 0.49–1.24; p = 0.298; aHR 0.71, 95%CI 0.50–1.02; p = 0.062). LTB was associated with increased 30-day mortality (aHR 5.60, 95%CI 2.49–12.61; p |
| Databáze: | OpenAIRE |
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