Correlation of five secretory proteins with the nasopharyngeal carcinoma metastasis and the clinical applications
| Autor: | Facai Cui, Zhi-Qiang Xiao, Kun Wang, Bin Yi, Ya Tao, Shiyang Qiu, Lepan Zhu, Manlin Xiang, Yunlai Liang, Lu Long, Yuan Jiang, Qiong Wu, Zhen Chen |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Oncology medicine.medical_specialty Pathology Metastasis 03 medical and health sciences 0302 clinical medicine Cell Line Tumor Internal medicine otorhinolaryngologic diseases Biomarkers Tumor medicine Humans metastasis Neoplasm Metastasis Stage (cooking) secretory proteins Lymph node serum tumor biomarker Nasopharyngeal Carcinoma business.industry Carcinoma Cancer Nasopharyngeal Neoplasms Middle Aged ADAMTSL4 Prognosis medicine.disease Blot stomatognathic diseases 030104 developmental biology medicine.anatomical_structure Secretory protein Nasopharyngeal carcinoma Lymphatic Metastasis 030220 oncology & carcinogenesis Biomarker (medicine) Female Clinical Research Paper business |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| Popis: | // Ya Tao 1,* , Kun Wang 1,* , Zhen Chen 1 , Lu Long 1 , Qiong Wu 1 , Facai Cui 1 , Lepan Zhu 1 , Manlin Xiang 1 , Yuan Jiang 1,2 , Yunlai Liang 1 , Shiyang Qiu 1 , Zhiqiang Xiao 3 and Bin Yi 1 1 Department of Clinical Laboratory, Xiangya Hospital, Central South University,Changsha,Hunan, China 2 Department of Clinical Laboratory, Hunan Cancer Hospital,Changsha,Hunan, China 3 The Higher Educational Key Laboratory for Cancer Proteomics and Translational Medicine of Hunan, Xiangya Hospital, Central South University, Changsha, Hunan, China * co-first authors Correspondence to: Bin Yi, email: // Keywords : nasopharyngeal carcinoma; metastasis; secretory proteins; serum tumor biomarker; ADAMTSL4 Received : August 23, 2016 Accepted : January 06, 2017 Published : January 18, 2017 Abstract In our previous study, five different secretory proteins, including GSN, ADAMTSL4, CALR, PPIA and TXN, have been identified to be associated with the nasopharyngeal carcinoma (NPC) metastasis.In this work, the 5 proteins were further investigated. Bioinformatics analysis suggested that they might play an important role in the process of NPC development.Western blotting analysis showed that all of these 5 targets could be secreted into extracellular by both high metastatic NPC 5-8F cells and non-metastatic NPC 6-10B cells. Except for GSN, the expressions of ADAMTSL4, CALR, PPIA and TXN proteins in extracts of the 5-8F and 6-10B cells were significantly different ( P < 0.05). Thus, the expressions of these 4 differentially expressed proteins were further tested in a cohort of NPC tissue specimens. The results indicated that the expression levels of ADAMTSL4 and TXN were highly correlated with the lymph node and distant metastasis ( P |
| Databáze: | OpenAIRE |
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