Innate immunity in solid organ transplantation: an update and therapeutic opportunities
| Autor: | Sacha A. De Serres, Stéphanie Béland, Patrice Vallin, Olivier Désy, Caroline Basoni |
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| Rok vydání: | 2015 |
| Předmět: |
Graft Rejection
Immunology chemical and pharmacologic phenomena Inflammation Context (language use) Transplantation Immunology medicine Immunology and Allergy Animals Humans Allorecognition Innate immune system business.industry Macrophages Innate lymphoid cell Antibodies Monoclonal Complement C5 Organ Transplantation biochemical phenomena metabolism and nutrition Acquired immune system Immunity Innate Transplantation Cytokines medicine.symptom Solid organ transplantation business Cell Adhesion Molecules Immunosuppressive Agents |
| Zdroj: | Expert review of clinical immunology. 11(3) |
| ISSN: | 1744-8409 |
| Popis: | Innate immunity is increasingly recognized as a major player in transplantation. In addition to its role in inflammation in the early post-transplant period, innate immunity shapes the differentiation of cells of adaptive immunity, with a capacity to promote either rejection or tolerance. Emerging data indicate that innate allorecognition, a characteristic previously limited to lymphocytes, is involved in allograft rejection. This review briefly summarizes the physiology of each component of the innate immune system in the context of transplantation and presents the current or promising therapeutic applications, such as cellular, anticomplement and anticytokine therapies. |
| Databáze: | OpenAIRE |
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