Interferon Gamma Release Assays for the Diagnosis of Latent TB Infection in HIV-Infected Individuals in a Low TB Burden Country
| Autor: | Nahla El-Eraki, Cliona Ni Cheallaigh, Susan Clarke, I. Fitzgerald, Jacinta Grace, Noel Gibbons, Gurmit Jagjit Singh, Colm Bergin, Thomas R. Rogers, Joseph Keane |
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| Rok vydání: | 2013 |
| Předmět: |
Bacterial Diseases
CD4-Positive T-Lymphocytes Male Health Screening HIV opportunistic infections QUANTIFERON-TB GOLD Human immunodeficiency virus (HIV) lcsh:Medicine HIV Infections medicine.disease_cause 0302 clinical medicine Hiv infected Prevalence Interferon gamma 030212 general & internal medicine lcsh:Science 0303 health sciences Multidisciplinary Latent tuberculosis Middle Aged Clinical Laboratory Sciences 3. Good health Medicine Infectious diseases Female Public Health Interferon-gamma Release Tests Viral load Research Article Test Evaluation medicine.drug Adult Tuberculosis Viral diseases Interferon-gamma 03 medical and health sciences Diagnostic Medicine Latent Tuberculosis medicine Humans Aged Tuberculin Test 030306 microbiology business.industry lcsh:R Tropical Diseases (Non-Neglected) HIV bacterial infections and mycoses medicine.disease Virology CD4 Lymphocyte Count Immunology lcsh:Q Clinical Immunology business |
| Zdroj: | PLoS ONE PLoS ONE, Vol 8, Iss 1, p e53330 (2013) |
| ISSN: | 1932-6203 |
| Popis: | Background Interferon gamma release assays (IGRAs) are used to diagnose latent tuberculosis infection. Two IGRAs are commercially available: the Quantiferon TB Gold In Tube (QFT-IT) and the T-SPOT.TB. There is debate as to which test to use in HIV+ individuals. Previous publications from high TB burden countries have raised concerns that the sensitivity of the QFT-IT assay, but not the T-SPOT.TB, may be impaired in HIV+ individuals with low CD4+ T-cell counts. We sought to compare the tests in a low TB burden setting. Methodology/Principal Findings T-SPOT.TB, QFT-IT, and tuberculin skin tests (TST) were performed in HIV infected individuals. Results were related to patient characteristics. McNemar’s test, multivariate regression and correlation analysis were carried out using SPSS (SPSS Inc). 256 HIV infected patients were enrolled in the study. The median CD4+ T-cell count was 338 cells/µL (range 1–1328). 37 (14%) patients had a CD4+ T-cell count of |
| Databáze: | OpenAIRE |
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