Polyprenylated Acylphloroglucinols With Different Carbon Skeletons From the Fruits of Garcinia multiflora
| Autor: | Wenli Xie, Yu Chen, Qingqing Li, Ziyu Ma, Haida Teng, Xueni Li, Guangzhong Yang |
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| Rok vydání: | 2021 |
| Předmět: |
antiproliferative activity
Circular dichroism biology Bicyclic molecule NMR calculations Chemistry Stereochemistry chemistry.chemical_element General Chemistry Nuclear magnetic resonance spectroscopy biology.organism_classification Garcinia multiflora polyprenylated acylphloroglucinols Ic50 values Garcinia QD1-999 Carbon Human cancer |
| Zdroj: | Frontiers in Chemistry, Vol 9 (2021) |
| ISSN: | 2296-2646 |
| DOI: | 10.3389/fchem.2021.756452 |
| Popis: | Eleven new polycyclic polyprenylated acylphloroglucinols (PPAPs, 1–11) and three new monocyclic polyprenylated acylphloroglucinols (MPAPs, 12–14), together with ten known analogues were isolated from the fruits of Garcinia multiflora. These PPAPs belong to three types including the bicyclic polyprenylated acylphloroglucinols (BPAPs), the caged PPAPs, and the complicated PPAPs. Their structures and absolute configurations were determined through HRESIMS, NMR spectroscopy data, electronic circular dichroism (ECD) calculations, and gauge-independent atomic orbital (GIAO) NMR calculations with DP4+ analyses. Moreover, compounds 2 and 7 exhibited moderate cytotoxicity against three human cancer lines (MCF-7, T98, and HepG2) with IC50 values ranging from 9.81 ± 1.56 to 17.00 ± 2.75 μM. |
| Databáze: | OpenAIRE |
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