Comparative population pharmacokinetics and absolute oral bioavailability of COX-2 selective inhibitors celecoxib, mavacoxib and meloxicam in cockatiels (Nymphicus hollandicus)
| Autor: | Gunther Antonissen, Patrick De Backer, Laura Dhondt, Mathias Devreese, Siegrid De Baere, Ronette Gehring, Tess Goessens, Siska Croubels, Roel Haesendonck |
|---|---|
| Přispěvatelé: | dIRAS RA-1 |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Mavacoxib
Cockatiels 040301 veterinary sciences lcsh:Medicine Administration Oral Cockatoos Pharmacology Meloxicam 030226 pharmacology & pharmacy Article 0403 veterinary science 03 medical and health sciences 0302 clinical medicine Pharmacokinetics FOOD Oral administration medicine Animals COXIBS Veterinary Sciences lcsh:Science Multidisciplinary BIRDS PLASMA Cyclooxygenase 2 Inhibitors business.industry lcsh:R HUMANS NONSTEROIDAL ANTIINFLAMMATORY DRUGS 04 agricultural and veterinary sciences PHARMACODYNAMICS Bioavailability PARROTS AMAZONA-VENTRALIS PATTERN DOGS Celecoxib Pharmacodynamics Pyrazoles lcsh:Q business medicine.drug |
| Zdroj: | Scientific Reports, 7(1). NLM (Medline) Scientific Reports SCIENTIFIC REPORTS Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017) |
| ISSN: | 2045-2322 |
| Popis: | Selective COX-2 inhibitors are non-steroidal anti-inflammatory drugs which directly target cyclooxygenase-2 (COX-2), an enzyme mainly responsible for induction of inflammation, pyresis and pain. Although commonly used in avian medicine, limited pharmacokinetic (PK) data in domestic and companion birds are available. In this study, PK parameters and absolute oral bioavailability expressed as percentage (F%) of celecoxib (10 mg/kg BW), mavacoxib (4 mg/kg BW) and meloxicam (1 mg/kg BW) were determined following single oral (PO) and intravenous (IV) administration to cockatiels (Nymphicus hollandicus). The drugs were quantified in plasma by liquid chromatography-tandem mass spectrometry. Data were processed using the nonlinear mixed effects (NLME) approach. In contrast to celecoxib (T1/2el = 0.88 h) and meloxicam (T1/2el = 0.90 h), mavacoxib has a prolonged elimination half-life (T1/2el = 135 h) following oral administration of a commercial formulation (CF). High to complete oral absorption was observed following oral administration of celecoxib (F% = 56–110%) and mavacoxib (F% = 111–113%), CF and standard solutions, respectively. In contrast, the F% of meloxicam was low (F% = 11%). Based on the presented results, a less frequent dosing of mavacoxib is proposed compared to celecoxib and meloxicam. However, pharmacodynamic and safety studies are necessary to further investigate the use of these NSAIDs in cockatiels. |
| Databáze: | OpenAIRE |
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