Prognostic value of the expression of chemokines and their receptors in regional lymph nodes of melanoma patients
| Autor: | Haiyan Mo, Dong Li, Xiang Zhou, Qian Liang, Ting-feng Xiong, Fuqiang Pan, Ruijin Luo |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
CCR1 Male Chemokine Skin Neoplasms CCR4 chemokine receptors chemokines Biology CD8-Positive T-Lymphocytes 03 medical and health sciences Chemokine receptor 0302 clinical medicine Immune system medicine Tumor Microenvironment Humans RNA Messenger tumour immunity Receptor Lymph node Melanoma CX3C CXC Macrophages Cell Biology Original Articles Middle Aged medicine.disease Prognosis CC XC 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Cancer research biology.protein Molecular Medicine Female Receptors Chemokine Original Article Lymph Nodes |
| Zdroj: | Journal of Cellular and Molecular Medicine |
| ISSN: | 1582-4934 |
| Popis: | Chemokines and their receptors have been reported to drive immune cells into tumours or to be directly involved in the promotion or inhibition of the development of tumours. However, their expression in regional lymph node (LN) tissues in melanoma patients remains unknown. The present study investigated the relationship between the expression of mRNA of chemokines and their receptors and clinicopathology of the regional LN tissues of skin cutaneous melanoma (SKCM) patients available in The Cancer Genome Atlas. The relationship between chemokines and their receptors and the composition of immune cells within the tumour was analysed. In SKCM regional LN tissues, the high expression of 32 types of chemokines and receptors, namely CCL2, 4‐5, 7‐8, 13, 22‐25, CCR1‐9, CXCL9‐13, 16, CXCR3, 5, 6, XCL1‐2 and XCR1 in LN was associated with favourable patient prognosis. Conversely, high expression of CXCL17 was an indicator of poor prognosis. The expression of mRNA for CXCL9‐11, 13, CXCR3, 6, CCL2, 4, 5, 7, 8, 25, CCR1, 2, 5, and XCL1, 2 in regional LN tissues was positively correlated with the fraction of CD8‐positive T cells and M1 macrophages, and was negatively correlated with M0 macrophages. CCR4, 6‐9, CCL13, 22, 23 and XCR1 were positively correlated with the fraction of memory B cells and naive T cells, and negatively correlated with M0 macrophages and resting mast cells, suggesting that chemokines and their receptors may affect the prognosis of patients by guiding immune cells into the tumour microenvironment to eliminate tumour cells. |
| Databáze: | OpenAIRE |
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