Animal model of methylphenidate's long-term memory-enhancing effects
| Autor: | Stephan G. Anagnostaras, Kleou Rasaei, Kristin K. Howell, Emilie T. Reas, Stephanie A. Carmack |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Conditioning Classical Pharmacology Inbred C57BL Atomoxetine Hydrochloride Medical and Health Sciences Developmental psychology Mice Cocaine Psychology Fear conditioning Nootropic Agents Propylamines Adrenergic Uptake Inhibitors Long-term memory Methylphenidate Fear Biological Sciences Reinforcement Mental Health Neuropsychology and Physiological Psychology Serotonin Uptake Inhibitors Attention Deficit Disorder (ADD) Female Drug Reinforcement Psychology Selective Serotonin Reuptake Inhibitors Locomotion medicine.drug Atomoxetine hydrochloride Memory Long-Term Cognitive Neuroscience Citalopram Long-Term Basic Behavioral and Social Science Dose-Response Relationship Cellular and Molecular Neuroscience Memory Behavioral and Social Science mental disorders medicine Animals Attention deficit hyperactivity disorder Maze Learning Amphetamine Bupropion Neurology & Neurosurgery Dose-Response Relationship Drug Research Psychology and Cognitive Sciences Atomoxetine Neurosciences medicine.disease Conditioned place preference Classical Brain Disorders Mice Inbred C57BL Reinforcement (Psychology) Space Perception Central Nervous System Stimulants Conditioning |
| Zdroj: | Learning & memory (Cold Spring Harbor, N.Y.), vol 21, iss 2 Carmack, SA; Howell, KK; Rasaei, K; Reas, ET; & Anagnostaras, SG. (2014). Animal model of methylphenidate's long-term memory-enhancing effects. Learning and Memory, 21(2), 82-89. doi: 10.1101/lm.033613.113. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/0wg3c8z0 |
| ISSN: | 1549-5485 |
| DOI: | 10.1101/lm.033613.113 |
| Popis: | Methylphenidate (MPH), introduced more than 60 years ago, accounts for two-thirds of current prescriptions for attention deficit hyperactivity disorder (ADHD). Although many studies have modeled MPH's effect on executive function, almost none have directly modeled its effect on long-term memory (LTM), even though improvement in LTM is a critical target of therapeutic intervention in ADHD. We examined the effects of a wide range of doses of MPH (0.01-10 mg/kg, i.p.) on Pavlovian fear learning, a leading model of memory. MPH's effects were then compared to those of atomoxetine (0.1-10 mg/kg, i.p.), bupropion (0.5-20 mg/kg, i.p.), and citalopram (0.01-10 mg/kg, i.p.). At low, clinically relevant doses, MPH enhanced fear memory; at high doses it impaired memory. MPH's memory-enhancing effects were not confounded by its effects on locomotion or anxiety. Further, MPH-induced memory enhancement seemed to require both dopamine and norepinephrine transporter inhibition. Finally, the addictive potential of MPH (1 mg/kg and 10 mg/kg) was compared to those of two other psychostimulants, amphetamine (0.005 mg/kg and 1.5 mg/kg) and cocaine (0.15 mg/kg and 15 mg/kg), using a conditioned place preference and behavioral sensitization paradigm. We found that memory-enhancing effects of psychostimulants observed at low doses are readily dissociable from their reinforcing and locomotor activating effects at high doses. Together, our data suggest that fear conditioning will be an especially fruitful platform for modeling the effects of psychostimulants on LTM in drug development. © 2014 Carmack et al. |
| Databáze: | OpenAIRE |
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