Prolactin Production by the Endometrium of Early Human Pregnancy*
| Autor: | Ila A. Maslar, Daniel H. Riddick, Anthony A. Luciano, Bruce M. Kaplan |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism Clinical Biochemistry In Vitro Techniques Cycloheximide Biology Endometrium Biochemistry chemistry.chemical_compound Endocrinology Pregnancy Internal medicine medicine Humans Blastocyst reproductive and urinary physiology Fetus urogenital system Biochemistry (medical) Trophoblast Decidual reaction female genital diseases and pregnancy complications Prolactin Trophoblasts Kinetics Pregnancy Trimester First medicine.anatomical_structure chemistry embryonic structures Female Pregnancy Tubal Fallopian tube |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 51:78-83 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jcem-51-1-78 |
| Popis: | PRL production by the decidualized endometrium of early pregnancy was investigated. Endometrium associated with trophoblast (n = 31) was obtained during therapeutic abortions performed 2–6 weeks post conception. Endometrium free of trophoblast (n = 4) was obtained from the uterine cavity immediately after the surgical removal of ectopic pregnancies in which the blastocyst had implanted within the distal portion of a Fallopian tube. When samples of these tissues were incubated in oxygenated Gey's buffer supplemented with 5% fetal calf serum, the concentration of PRL in the medium increased progressively. After 24 h, the total hormone content of the tissue plus medium was significantly greater than the initial hormone content of the tissue before incubation. When protein synthesis was inhibited by the addition of 50 μg/ml cycloheximide to the medium, the amount of PRL produced during incubation was markedly reduced. The four samples of endometrium which contained no tissue of fetal origin due to tubal impla... |
| Databáze: | OpenAIRE |
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