Human papillomavirus in oral premalignant lesions
| Autor: | Palle Holmstrup, F Praetorius, Henrik Winther Nielsen, B. Norrild, P. Vedtofte, Jesper Reibel |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
Male Cancer Research Pathology medicine.medical_specialty Biology medicine.disease_cause Polymerase Chain Reaction law.invention Malignant transformation Age Distribution law medicine Humans Sex Distribution Oral mucosa Papillomaviridae In Situ Hybridization Polymerase chain reaction Aged Aged 80 and over Cervical cancer Erythroplakia HPV infection virus diseases Mucous membrane Middle Aged medicine.disease female genital diseases and pregnancy complications Blotting Southern medicine.anatomical_structure Oncology Erythroplasia Female Mouth Neoplasms Leukoplakia Oral Carcinogenesis |
| Zdroj: | European Journal of Cancer Part B: Oral Oncology. 32:264-270 |
| ISSN: | 0964-1955 |
| DOI: | 10.1016/0964-1955(96)00011-5 |
| Popis: | The aetiology of oral premalignant lesions is generally accepted to be multifactorial. Tobacco and alcohol are established as important cofactors in malignant development in the oral cavity, but in addition microorganisms, such as human papillomavirus (HPV), have gained much interest over the past decade. For many years, HPV has been accepted as an important cofactor in the development of cervical cancer, originating from a mucous membrane with similarities to the oral mucosa. 49 patients with oral premalignant lesions and 20 control patients with normal oral mucosa and no history of HPV infection were examined for the presence of HPV by immune histochemical staining using the peroxidase anti-peroxidase technique (PAP), DNA-DNA in situ hybridisation (ISH), and polymerase chain reaction (PCR) analysed by Southern blot hybridisation with an HPV 16 specific probe. The investigations revealed that HPV was found in 62.5% of the verrucous leucoplakias, 50.0% of the erythroplakias, 45.5% of the homogeneous leucoplakias, 33.3% of erythroleucoplakias and in 12.5% of the nodular leucoplakias. An overall HPV detection rate in the examined premalignant lesions was 40.8% and no patients in the control sample were positive. Concerning oral cancer development, it seems likely that HPV may be a cofactor, as 100% of patients who developed oral cancers within 4-12 years were all positive for HPV, one being positive for HPV 16. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect