A need for cautious interpretation of elevated serum germ cell tumor markers in children. Review and own experiences
| Autor: | Malgorzata Krawczyk, Joanna Stefanowicz, Elżbieta Drożyńska, Katarzyna Połczyńska, Anna Płoszyńska, Ewa Bien, Gabrielle Karpinsky, Beata Zalewska-Szewczyk, Ewa Izycka-Swieszewska |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Pathology medicine.medical_specialty Adolescent medicine.drug_class medicine.medical_treatment Clinical Biochemistry Pancreatoblastoma Elevated serum Drug Discovery medicine Biomarkers Tumor Humans Chorionic Gonadotropin beta Subunit Human Diagnostic Errors Intrahepatic Cholangiocarcinoma Chemotherapy business.industry Biochemistry (medical) Neoplasms Germ Cell and Embryonal medicine.disease digestive system diseases Tumor Burden medicine.anatomical_structure Child Preschool Female Germ cell tumors alpha-Fetoproteins Differential diagnosis Gonadotropin business Germ cell |
| Zdroj: | Biomarkers in medicine. 9(9) |
| ISSN: | 1752-0371 |
| Popis: | Protocols for pediatric germ cell tumors (GCT) allow for chemotherapy (CHT) initiation without histological diagnosis, based on typical clinical and radiological picture and increased alphafetoprotein (AFP) or beta-human chorionic gonadotropin serum levels. Such strategy may result in misdiagnoses in rare cases. We present two patients with abdominal tumors and high serum AFP levels, diagnosed as GCT. In both, no tumor shrinkage and increasing AFP was observed after first cycles of multidrug CHT for pediatric GCT. Histological examination of biopsied tumor tissues revealed metastatic cholangiocarcinoma in patient 1 and pancreatoblastoma in patient 2, which implicated immediate change of therapy. Presented cases support the necessity to consider the tumor biopsy when patients diagnosed with GCT based on typical clinical presentation and elevated AFP do not respond to CHT with AFP decrease and tumor size reduction. |
| Databáze: | OpenAIRE |
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