Polymer-supported tetrafluorophenol: a new activated resin for chemical library synthesis

Autor:	Joseph M. Salvino, M. Gardyan, Rose Mathew, Richard Labaudiniere, Krolikowski D, Crawford K, Terence Kiesow, Orton E, Kumar Nv, Krolikowski P, John E. Airey, Mark D. Drew, Gerard McGeehan, D. Engers, Timothy F. Herpin
Rok vydání:	2000
Předmět:	Acylation chemistry.chemical_compound Primary (chemistry) Sulfonate stomatognathic system Scope (project management) chemistry technology industry and agriculture General Chemistry Fluorine-19 NMR Combinatorial chemistry Polymer supported Chemical library
Zdroj:	Journal of combinatorial chemistry. 2(6)
ISSN:	1520-4766
Popis:	A new tetrafluorophenol activated resin that facilitates the use of 19F NMR to quantitate loading is presented. This new resin provides a useful tool for acylation, and a novel activated polymeric sulfonate ester to generate sulfonamides. This activated resin reacts with a wide scope of N-nucleophiles including primary and secondary amines, and anilines. This new activated resin methodology provides a powerful tool for pure single-compound library synthesis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56f9482e89588e73a2b02ced3b6f8f5c https://pubmed.ncbi.nlm.nih.gov/11126297 Zobrazit plný text záznamu