Plasmodium gallinaceum: changing virulence patterns of malaria parasites during adaptation from neonate chick to chicken embryos
| Autor: | Lushbaugh Wb, S. D. Singh, R. B. Mcghee |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Male
Plasmodium animal structures Immunology Adaptation Biological Virulence Chick Embryo Biology Plasmodium gallinaceum Avian malaria medicine Parasite hosting Animals Embryo General Medicine medicine.disease biology.organism_classification Virology Infectious Diseases Blood Animals Newborn embryonic structures Parasitology Hemoglobin Adaptation Chickens Malaria |
| Zdroj: | Experimental parasitology. 43(1) |
| ISSN: | 0014-4894 |
| Popis: | Infections of avian embryos with Plasmodium gallinaceum from a malaria strain adapted to continuous passage in chicks were characterized by reduced virulence. Five passages through embryos were required to produce infections comparable to those observed in established infections. If blood from a chicken infected by sporozoites was injected into 10-day chicken embryos there were a marked loss of virulence, heightened pathogenicity, and morphological aberrations. Increasing the dosage from a million to 20 × 10 6 parasites resulted in parasitemias more nearly resembling those in fully adapted passages in chicken embryos. Blood passages from chicken to chicken somehow changed the parasite to the point that after four passages acute virulent infections could be obtained in the embryo. It is postulated that the chicken embryo by virtue of its difference from neonates as regards plasma elements and physiochemical composition of its erythrocytes, especially in the hemoglobin, constitutes essentially a foreign host to which a few parasites are preadapted. During blood passages selection toward virulence ensues. |
| Databáze: | OpenAIRE |
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