ENERGY AND SUBSTRATE METABOLISM IN PATIENTS WITH CHRONIC EXTENSIVE GRAFT-VERSUS-HOST DISEASE
| Autor: | Hildegard Greinix, Bruno Schneeweiss, Klaus Ratheiser, Christian Zauner, Peter Kalhs, Mark Schiefermeier, Werner Rabitsch, Felix Keil |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Graft vs Host Disease Carbohydrate metabolism Glucagon Blood Urea Nitrogen Weight loss Internal medicine medicine Humans Resting energy expenditure Blood urea nitrogen Transplantation business.industry Middle Aged medicine.disease Respiratory quotient Endocrinology Graft-versus-host disease Chronic Disease Lactates Female medicine.symptom Energy Metabolism business |
| Zdroj: | Transplantation. 71:524-528 |
| ISSN: | 0041-1337 |
| Popis: | Background. Allogeneic stem cell transplantation is frequently complicated by graft-versus-host disease (GVHD). Weight loss is one of the characteristic features of GVHD. The etiology of weight loss in GVHD is not completely understood. Methods. We measured resting energy expenditure (REE) and substrate oxidation rates by indirect calorimetry in patients with stable chronic extensive GVHD under immunosuppressive therapy (n513) and sex-, age-, height-, and weight-matched healthy controls (n513) in order to evaluate metabolic changes in these patients. Measurements were done on day 5186261 after allogeneic stem cell transplantation in the postabsorptive state. Serum concentrations of glucagon, norepinephrine, tumor necrosis factor-a, interleukin-6, and free fatty acids were determined. Results. Patients showed a maximum weight loss of 22% during their course of GVHD; nevertheless, they regained 15% of total body weight (TBW) during successful treatment of GVHD. Indirect calorimetry showed an increase in REE per kilogram of TBW (patients, 21.863.1 kcal/kg TBW/day; controls, 19.962 kcal/kg TBW/day; P |
| Databáze: | OpenAIRE |
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