The zinc finger gene Xblimp1 controls anterior endomesodermal cell fate in Spemann's organizer
| Autor: | Aitana Perea Gómez, Volker Gawantka, Hajo Delius, Christof Niehrs, Siew-Lan Ang, Flavio S. J. de Souza |
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| Rok vydání: | 1999 |
| Předmět: |
Mesoderm
animal structures Microinjections Xenopus Molecular Sequence Data Biology Cell fate determination Xenopus Proteins General Biochemistry Genetics and Molecular Biology Endomesoderm Cerberus (protein) medicine Animals Amino Acid Sequence RNA Messenger Cloning Molecular Molecular Biology In Situ Hybridization Glycoproteins Zinc finger Embryonic Induction Homeodomain Proteins General Immunology and Microbiology General Neuroscience Gene Expression Regulation Developmental Proteins Zinc Fingers Molecular biology Gastrulation Repressor Proteins medicine.anatomical_structure embryonic structures Bone Morphogenetic Proteins Intercellular Signaling Peptides and Proteins Endoderm Chordin Head Sequence Alignment Research Article |
| Zdroj: | The EMBO journal. 18(21) |
| ISSN: | 0261-4189 |
| Popis: | The anterior endomesoderm of the early Xenopus gastrula is a part of Spemann's organizer and is important for head induction. Here we describe Xblimp1, which encodes a zinc finger transcriptional repressor expressed in the anterior endomesoderm. Xblimp1 represses trunk mesoderm and induces anterior endomesoderm in a cooperative manner with the pan-endodermal gene Mix.1. Furthermore, Xblimp1 can cooperate with the BMP inhibitor chordin to induce ectopic heads, while a dominant-negative Xblimp1 inhibits head formation. The head inducer cerberus is positively regulated by Xblimp1 and is able to rescue microcephalic embryos caused by dominant-negative Xblimp1. Our results indicate that Xblimp1 is required for anterior endomesodermal cell fate and head induction. |
| Databáze: | OpenAIRE |
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