Question 2: Should thrombolytic agents be used in children presenting with acute ischaemic stroke?
| Autor: | Nahin Hussain, Dhinesh Baskaran |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Pediatrics
medicine.medical_specialty Neurology Vascular disease business.industry media_common.quotation_subject medicine.medical_treatment MEDLINE Thrombolysis Evidence-based medicine Neonatal age medicine.disease 03 medical and health sciences 0302 clinical medicine Hemiparesis Pediatrics Perinatology and Child Health medicine Physical therapy 030212 general & internal medicine Girl medicine.symptom business 030217 neurology & neurosurgery media_common |
| Zdroj: | Archives of Disease in Childhood. 102:382-387 |
| ISSN: | 1468-2044 0003-9888 |
| Popis: | Structured clinical question In children (1 month to 18 years) outside the neonatal age range presenting with acute ischaemic stroke (AIS), does thrombolysis help improve neurological outcome? If so, within what time frame does this need to occur in order to be effective? ### Outcome of evidence search Thrombolysis is not clearly of benefit in children presenting with AIS. A previously fit and well 12-year-old girl presents to accident and emergency (A&E) in the middle of the night with an acute-onset left-sided hemiparesis. She was last seen well before bed 3 hours ago. The clinical impression is that she has had a cerebro-vascular accident secondary to an acute ischaemic insult. An urgent out of hours CT head is carried out, which shows ‘hypodense changes in the region of the right middle cerebral artery’. Your A&E colleagues state that they thrombolyse adult patients presenting like this. Do you proceed to thrombolyse this young girl? In children (1 month to 18 years) outside the neonatal age range (patient group) presenting with AIS (condition), does thrombolysis (intervention) help improve neurological outcome (outcome)? If so, within what time frame does this need to occur in order to be effective? ### Primary sources Medline through PubMed was searched using the search strategy given below: MEDLINE stroke.ti,ab [Limit to: (Age Groups All Child 0–18 years) and (Languages English)] AND (thrombolysis OR thrombolytic AND agent OR alteplase OR … |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|