millepattesmicropeptides are an ancient developmental switch required for embryonic patterning
| Autor: | François Payre, Martin Klingler, S. K. Ray, Matthias Teuscher, Rosenberg Mi, Hélène Chanut-Delalande, Amélie Decaras, Irene Schnellhammer, Tzach Auman, Abderrahman Khila, Barbara Schwertner, William Toubiana |
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| Rok vydání: | 2018 |
| Předmět: |
0303 health sciences
animal structures biology fungi 030302 biochemistry & molecular biology Embryo Ubiquitin ligase Trichome patterning Cell biology 03 medical and health sciences Open reading frame biology.protein Gene Blastoderm Developmental biology Function (biology) 030304 developmental biology |
| Popis: | SummarySmall open reading frames (smORFs) that code for “micropeptides” (10-100 amino acids) exhibit remarkable evolutionary complexity. Conserved micropeptides encoded by themillepattes (mlpt)gene are essential inTriboliumfor embryogenesis but inDrosophila,function only in leg and cuticle differentiation. We find that a module identified inDrosophilatrichome patterning, comprising Mlpt, UBR3, and Shaven-baby (Svb), coordinates early embryo patterning in several insect orders. Intriguingly, Mlpt segmentation function can be re-awakened in theDrosophilablastoderm, demonstrating the potency of an ancestral developmental switch retained despite evolving embryonic patterning modes. smORFs likemillepattesthus illustrate plasticity of micropeptide functions despite constraints of essential genetic networks.One sentence summaryA module comprising the small ORFs mlpt/pri/tal, the transcription factor Svb, and the ubiquitin ligase UBR3, possesses an ancestral function in insect embryo patterning which is lost in flies but reactivated when Svb expression is restored. |
| Databáze: | OpenAIRE |
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