Signal transducers and activators of transcription 3 function in lung cancer
| Autor: | Jian-Hui Pan, Chun-Jie Li, Yue-Chuan Li, Dong-Rui Zhang |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
STAT3 Transcription Factor
Lung Neoplasms medicine.disease_cause lcsh:RC254-282 stat Carcinoma Non-Small-Cell Lung medicine Animals Humans Radiology Nuclear Medicine and imaging Epidermal growth factor receptor signal transducers and activators of transcription 3 Lung cancer STAT3 Cell Proliferation biology Kinase General Medicine lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease Cell biology Gene Expression Regulation Neoplastic lung cancer Oncology Second messenger system Disease Progression biology.protein Signal transduction Cell competition epidermal growth factor receptor Carcinogenesis Signal Transduction |
| Zdroj: | Journal of Cancer Research and Therapeutics, Vol 9, Iss 5, Pp 67-73 (2013) |
| ISSN: | 0973-1482 |
| DOI: | 10.4103/0973-1482.119100 |
| Popis: | Constitutively activation of signal transducers and activators of transcription 3 (STAT3) proteins are involved in multiple aberrant signaling pathway-oncogenic pathways, including pathways regulating tumor cell survival. STAT3 is one of the second messengers in the Janus activated family kinases/STAT signaling pathway and is regulated by many different factors involving tumorigenesis. Given that the activation of STAT3 is observed in nearly 50% of Lung cancers and more and more researches regarding STAT3 in tumors, here in, we reviewed the contribution of STAT3 to lung cancer growth and progression and then the context in which positive and negative regulation of STAT activation leading to cell competition provides a mechanism for therapeutic intervention for specific cancers is discussed. |
| Databáze: | OpenAIRE |
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