The Effect of Visible Light on the Gunn Rat: Convulsive Threshold, Bilirubin Concentration, and Brain Color
| Autor: | Thomas R. C. Sisson, Barry Slaven, Steven E. Goldberg |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Heterozygote
medicine.medical_specialty Ataxia Cerebellar Ataxia Bilirubin Color chemistry.chemical_compound Fluorescent light Seizures In vivo Cerebellum Internal medicine medicine Animals Humans Hyperbilirubinemia Brain Diseases Chemistry Body Weight Homozygote Infant Newborn Convulsive threshold Brain Dose-Response Relationship Radiation Phototherapy Gunn rat Jaundice Neonatal Surgery Bilirubin concentration Disease Models Animal Endocrinology Pediatrics Perinatology and Child Health medicine.symptom Visible spectrum |
| Zdroj: | Pediatric Research. 8:647-651 |
| ISSN: | 1530-0447 0031-3998 |
| DOI: | 10.1203/00006450-197406000-00005 |
| Popis: | Extract: Irradiation of congenitally jaundiced rats from the 1st–21st days of life by visible light emitting between 420 and 470 nm is effective in preventing hyperbilirubinemia, brain discoloration by bilirubin, and ataxia, in maintaining normal cerebellar size, and in preserving normal convulsive threshold. These findings indicate the prevention of bilirubin encephalopathy. Irradiation by “daylight” fluorescent light was only partially effective. The results of this study also indicate that in vivo photodecomposition of bilirubin has a dose-response relation to the emission in the absorbance range of the pigment. Speculation: The prevention of bilirubin encephalopathy in human neonates during phototherapy may be enhanced by the direct action of visible light on bilirubin circulating in the vessels of the brain. The transmission of light into this organ would be a fruitful area of study to confirm or discard this hypothesis. Measurement of the convulsive threshold of suitable animals may offer a quantified basis of comparison of various phototherapeutic regimens in the study of hyperbilirubinemia. |
| Databáze: | OpenAIRE |
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