Ethnobotany, ethnopharmacology, and phytochemistry of traditional medicinal plants used in the management of symptoms of tuberculosis in East Africa: a systematic review
Autor: | Mark Peter Odero, Samuel Baker Obakiro, Ambrose Kiprop, Elizabeth Kigondu, Timothy Omara, Lydia Bunalema, Isaac O. K’Owino |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
Warburgia ugandensis
Phytochemistry lcsh:Arctic medicine. Tropical medicine medicine.drug_class lcsh:RC955-962 030231 tropical medicine Phytochemicals Review Antimycobacterial Antitubercular 03 medical and health sciences 0302 clinical medicine Medicinal plants medicine 030212 general & internal medicine biology Traditional medicine Public Health Environmental and Occupational Health Euphorbiaceae Fabaceae Mycobacterium tuberculosis biology.organism_classification Infectious Diseases Ethnobotany Lamiaceae Herbal medicine |
Zdroj: | Tropical Medicine and Health, Vol 48, Iss 1, Pp 1-21 (2020) Tropical Medicine and Health |
ISSN: | 1349-4147 |
Popis: | ObjectiveMany studies on the treatment of tuberculosis (TB) using herbal medicines have been undertaken in recent decades in East Africa. The details, however, are highly fragmented. The purpose of this study was to provide a comprehensive overview of the reported medicinal plants used to manage TB symptoms, and to analyze scientific reports on their effectiveness and safety.MethodA comprehensive literature search was performed in the major electronic databases regarding medicinal plants used in the management of TB in East Africa. A total of 44 reports were retrieved, and data were collected on various aspects of the medicinal plants such as botanical name, family, local names, part(s) used, method of preparation, efficacy, toxicity, and phytochemistry. The data were summarized into percentages and frequencies which were presented as tables and graphs.ResultsA total of 195 species of plants belonging to 68 families and 144 genera were identified. Most encountered species were from Fabaceae (42.6%), Lamiaceae (19.1%), Asteraceae (16.2%), and Euphorbiaceae (14.7%) families. Only 36 medicinal plants (18.5%) have been screened for antimycobacterial activity. Out of these, 31 (86.1%) were reported to be bioactive with minimum inhibitory concentrations ranging from 47 to 12,500 μg/ml. Most tested plant extracts were found to have acceptable acute toxicity profiles with cytotoxic concentrations on normal mammalian cells greater than 200 μg/ml. The most commonly reported phytochemicals were flavonoids, terpenoids, alkaloids, saponins, cardiac glycosides, and phenols. OnlyTetradenia riparia,Warburgia ugandensis, andZanthoxylum leprieuriihave further undergone isolation and characterization of the pure bioactive compounds.ConclusionEast Africa has a rich diversity of medicinal plants that have been reported to be effective in the management of symptoms of TB. More validation studies are required to promote the discovery of antimycobacterial drugs and to provide evidence for standardization of herbal medicine use. |
Databáze: | OpenAIRE |
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