A prospective randomized controlled trial on the value of prophylactic oral nutritional supplementation in locally advanced nasopharyngeal carcinoma patients receiving chemo-radiotherapy
| Autor: | Yuan-Yuan Chen, Yonghong Hua, Wei Sheng, Feng Jiang, Shuang Huang, Jia Chen, Qiaoying Hu, Xiaozhong Chen, Zekai Shu, Caineng Cao, Yongfeng Piao |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Time Factors Nutritional Supplementation medicine.medical_treatment Nutritional Status law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial Quality of life law Weight loss Internal medicine Weight Loss medicine Humans Prospective Studies 030223 otorhinolaryngology Chemotherapy Analysis of Variance Nasopharyngeal Carcinoma business.industry Nutritional Support Body Weight Malnutrition Nasopharyngeal Neoplasms Chemoradiotherapy Middle Aged medicine.disease Neoadjuvant Therapy Radiation therapy Oncology Nasopharyngeal carcinoma Withholding Treatment Chemotherapy Adjuvant 030220 oncology & carcinogenesis Quality of Life Female Oral Surgery medicine.symptom business |
| Zdroj: | Oral oncology. 111 |
| ISSN: | 1879-0593 |
| Popis: | Objectives We investigated the effect of prophylactic oral nutrition supplements (ONS) in locally advanced nasopharyngeal carcinoma patients receiving neoadjuvant chemotherapy and concurrent chemoradiotherapy (CCRT). Methods Eligible patients were randomly assigned to an intervention or control group. Patients in the intervention group were supported with prophylactic ONS from the beginning of CCRT. The control group received nutritional support only when necessary. Bodyweight, hematological indexes, nutritional status, and quality of life were measured at baseline and before, during, and after RT. Results We evaluated 114 patients from October 2016 to May 2018. More than half of patients experienced significant weight loss during CCRT, which continued for three months after radiotherapy (RT). Compared to baseline, the rate of weight loss ≥ 5% before, during, at the end of RT, and one and three months after RT were 3.5%, 28.9%, 51.8%, 61.4%, and 61.4%, respectively. Nutritional status and global health status scores progressively decreased during treatment. The rate of RT interruption was higher in the control group than in the intervention group (7.14% vs. 0%, χ2 = 4.29, P = 0.04). More patients experienced concurrent chemotherapy interruption in the control group than in the intervention group (28.57% vs 10.34%, χ2 = 6.08, P = 0.01). There were no significant differences in weight loss, nutritional status, quality of life, and global health status between two groups. Conclusions Malnutrition and weight loss progressively increased during treatment. Prophylactic ONS can improve tolerance to CCRT, but it offers no advantage on short-term weight loss or nutritional assessment scores. |
| Databáze: | OpenAIRE |
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