Unraveling the Armor of a Killer: Evasion of Host Defenses by African Swine Fever Virus
| Autor: | AlessanRSS Reis, Christopher Netherton, Ana Luisa Reis, Linda Dixon |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Swine viruses Immunology Microbiology African swine fever virus Virus 03 medical and health sciences Asfarviridae Interferon Virology medicine Animals Macrophage African Swine Fever Immune Evasion Gem biology Host (biology) Macrophages DNA virus biology.organism_classification African Swine Fever Virus Immunity Innate 030104 developmental biology Apoptosis Insect Science Host-Pathogen Interactions medicine.drug |
| Zdroj: | Journal of Virology. 91 |
| ISSN: | 1098-5514 0022-538X |
| DOI: | 10.1128/jvi.02338-16 |
| Popis: | African swine fever is an acute hemorrhagic disease of pigs. Extensive recent spread in the Russian Federation and Eastern Europe has increased the risk to global pig production. The virus is a large DNA virus and is the only member of the Asfarviridae family. In pigs, the virus replicates predominantly in macrophages. We review how the virus overcomes the barriers to replication in the macrophage and the virus mechanism to inhibit key host defense pathways. |
| Databáze: | OpenAIRE |
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