Role Of Neurotrophin Receptor p75NTR In Mediating Neuronal Cell Death Following Injury
| Autor: | Kate Reid, Simon S. Murray, S. S. Cheema, Perry F. Bartlett, Elizabeth J. Coulson |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Neurons
Pharmacology Programmed cell death Cell Death biology Physiology Down-Regulation Cell biology Nerve growth factor Apoptosis Physiology (medical) Trans-Activators biology.protein Animals Humans Wounds and Injuries sense organs Signal transduction Transcription factor Caspase Adaptor Proteins Signal Transducing Signal Transduction Transcription Factors Death domain Neurotrophin |
| Zdroj: | Clinical and Experimental Pharmacology and Physiology. 27:537-541 |
| ISSN: | 1440-1681 0305-1870 |
| DOI: | 10.1046/j.1440-1681.2000.03295.x |
| Popis: | 1. The neurotrophin receptor p75NTR has been shown to mediate neuronal cell death after nerve injury. 2. Down-regulation of p75NTR by antisense oligonucleotides is able to inhibit both sensory and motor neuron death and this treatment is more effective than treatment with growth factors. 3. p75NTR induces cell death by a unique death signalling pathway involving transcription factors (nuclear factor kappa B and c-jun), Bcl-2 family members and caspases. |
| Databáze: | OpenAIRE |
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