Severe chronic osteomyelitis caused by Morganella morganii with high population diversity
| Autor: | Li Li, Haifeng Li, Jialiang Zhu, Ruoyan Li, Wenfeng Li, Min Yang, Fan Bai, Minshan Liu, Ronggong Yang, Li Feng, Lin Yang, Shuxun Hou, Yuehua Ke |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male 0301 basic medicine Microbiology (medical) 030106 microbiology Genetic diversity Microbiology lcsh:Infectious and parasitic diseases 03 medical and health sciences Morganella polycyclic compounds Humans lcsh:RC109-216 Chronic osteomyelitis Gene Phylogeny Morganella morganii Whole genome sequencing Whole-genome sequencing biology Host (biology) Enterobacteriaceae Infections Osteomyelitis Biodiversity General Medicine biochemical phenomena metabolism and nutrition biology.organism_classification 16S ribosomal RNA 030104 developmental biology Infectious Diseases bacteria |
| Zdroj: | International Journal of Infectious Diseases, Vol 50, Iss C, Pp 44-47 (2016) |
| ISSN: | 1201-9712 |
| DOI: | 10.1016/j.ijid.2016.07.016 |
| Popis: | SummaryA case of chronic osteomyelitis probably caused by Morganella morganii, occurring over a period of 30 years, is reported. The organism was identified through a combination of sample culture, direct sequencing, and 16S RNA gene amplicon sequencing. Further whole-genome sequencing and population structure analysis of the isolates from the patient showed the bacterial population to be highly diverse. This case provides a valuable example of a long-term infection caused by an opportunistic pathogen, M. morganii, with high diversity, which might evolve during replication within the host. |
| Databáze: | OpenAIRE |
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