Population structure of multidrug-resistant Mycobacterium tuberculosis clinical isolates in Colombia
| Autor: | David Couvin, Lorena Argoty-Chamorro, Martha Isabel Murcia, Claudia Llerena, Julio Guerra, Juan Germán Rodríguez-Castillo, Nalin Rastogi |
|---|---|
| Přispěvatelé: | Universidad Nacional de Colombia [Bogotà] (UNAL), Instituto Nacional de Salud [Bogota], Unité de la Tuberculose et des Mycobactéries - WHO Supranational TB Reference Laboratory, Institut Pasteur de la Guadeloupe, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), The work related to molecular biology received the support of Departamento de Microbiología, Facultad de Medicina, Universidad Nacional de Colombia. |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male 0301 basic medicine Microbiology (medical) Tuberculosis Genotype 030106 microbiology Immunology Population structure Antitubercular Agents Colombia Microbiology MIRU-VNTR Mycobacterium tuberculosis 03 medical and health sciences Tuberculosis Multidrug-Resistant medicine Humans Multidrug-resistant Multidrug-Resistant Mycobacterium tuberculosis Retrospective Studies Spoligotyping Molecular epidemiology biology Incidence biology.organism_classification medicine.disease [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology Virology 3. Good health Multiple drug resistance 030104 developmental biology Infectious Diseases Mycobacterium tuberculosis complex Female |
| Zdroj: | Tuberculosis Tuberculosis, Elsevier, 2020, 125, pp.102011. ⟨10.1016/j.tube.2020.102011⟩ |
| ISSN: | 1472-9792 |
| DOI: | 10.1016/j.tube.2020.102011 |
| Popis: | International audience; Emergence of multidrug-resistant (MDR) Mycobacterium tuberculosis complex (MTBC) isolates is a major public health problem that threatens progress made in tuberculosis (TB) care and control worldwide. In Colombia, the prevalence of MDR tuberculosis (MDR-TB) has increased slowly but steadily since 2001. However, the population structure of the MDR-TB strains circulating in Colombia is sparsely known. In this work, 203 MDR isolates isolated in 2012-2013 were collected, and characterized by spoligotyping, followed by 24-loci MIRU-VNTR (data available for 190 isolates). The most prevalent genotypes corresponded to SIT42/LAM9 (12.81%), SIT62/H1 (10.34%), and SIT190/Beijing (10.34%). A fine analysis showed that although the MDR strains came from 29 of the 33 departments of Colombia, the distribution of these main lineages was not at random and depended on the city of isolation (p-value |
| Databáze: | OpenAIRE |
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