Locomotor Responses and Neuron Excitability in Conditions of Haloperidol Blockade of Dopamine in Invertebrates and Vertebrates
| Autor: | S. S. Arkhipova, A. I. Golubev, L. N. Muranova, N. V. Zvezdochkina, I. N. Pleshchinskii, V. V. Andrianov, Kh. L. Gainutdinov |
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| Rok vydání: | 2006 |
| Předmět: |
medicine.medical_specialty
Time Factors Motor Activity Membrane Potentials H-Reflex Dopamine Internal medicine medicine Haloperidol Animals Muscle Skeletal Neurons Behavior Animal Dose-Response Relationship Drug Chemistry Helix Snails General Neuroscience Long-term potentiation Hyperpolarization (biology) Electric Stimulation Ganglia Invertebrate Rats Blockade medicine.anatomical_structure Endocrinology Spinal Cord Dopamine receptor Threshold potential Dopamine Antagonists Neuron Neuroscience medicine.drug |
| Zdroj: | Neuroscience and Behavioral Physiology. 36:21-27 |
| ISSN: | 1573-899X 0097-0549 |
| Popis: | Levels of movement activity were used to identify two groups of rats: those with high- and low-activity levels. Blockade of dopamine receptors with haloperidol led to suppression of locomotor activity in both groups of rats; in common snails, haloperidol decreased the rate of locomotion. The excitability of spinal centers in rats decreased 5 min after single i.v. injections, with gradual recovery seen by 30 min. Chronic administration of haloperidol suppressed post-tetanic potentiation of the H response in the gastrocnemius muscle of spinal rats. Prolonged use of haloperidol induced significant hyperpolarization of the membrane potential of command neurons in common snails and increased the action potential generation threshold. Selective pharmacological exclusion of the brain dopamine system was found to lead to decreases in the excitability of defined neurons in snails and the spinal motor centers in rats, also producing impairments in locomotor responses in these animals. |
| Databáze: | OpenAIRE |
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