Fungicidal Activity in the Presence of Keratin as an Important Factor Contributing to In Vivo Efficacy: A Comparison of Efinaconazole, Tavaborole, and Ciclopirox
| Autor: | Yoshiyuki Tatsumi, Haruki Tachibana, Naomichi Kumagai |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Microbiology (medical) 030106 microbiology topical antifungal Plant Science Pharmacology Article 03 medical and health sciences In vivo Keratin onychomycosis medicine keratin lcsh:QH301-705.5 Efinaconazole Ecology Evolution Behavior and Systematics chemistry.chemical_classification fungicidal activity Tavaborole Ciclopirox business.industry drug effect Broth microdilution Topical antifungal Fungicide lcsh:Biology (General) chemistry business medicine.drug |
| Zdroj: | Journal of Fungi, Vol 3, Iss 4, p 58 (2017) Journal of Fungi Journal of Fungi; Volume 3; Issue 4; Pages: 58 |
| ISSN: | 2309-608X |
| Popis: | Use of oral antifungals in the treatment of onychomycosis is commonplace; but their use can be limited by safety and patient concerns. Due to their broader safety margins, topical antifungals (efinaconazole, tavaborole, and ciclopirox) are a useful option in the treatment of mild-to-moderate onychomycosis in the USA, but their antifungal activity has yet to be directly compared. This study aims to identify important factors contributing to in vivo efficacies of the three topical antifungals. Minimum inhibitory concentrations (MICs) were determined by Clinical and Laboratory Standards Institute (CLSI) M38-A2 broth microdilution. The MIC90 values of efinaconazole, tavaborole, and ciclopirox for T. rubrum were 0.0078, 8.0, and 0.50 μg/mL, respectively. The MIC90 values for T. mentagrophytes were 0.016, 8.0, and 0.50 μg/mL, respectively. Efinaconazole showed potent fungicidal activity in keratin-containing medium, whereas tavaborole was fungistatic, and ciclopirox not active. In the guinea pig model of onychomycosis, the therapeutic efficacy of efinaconazole was superior to those of tavaborole and ciclopirox. This study suggests that not only fungistatic activity (MIC), but also fungicidal activity in the presence of keratin, is an important factor contributing to the in vivo efficacy of topical antifungal drugs against onychomycosis. |
| Databáze: | OpenAIRE |
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