The effect of reduced glomerular filtration rate on plasma total homocysteine concentration
| Autor: | Hans Thysell, Peter Nilsson-Ehle, M Arnadottir, Björn Hultberg |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
Male medicine.medical_specialty Erythrocytes Homocysteine medicine.medical_treatment Clinical Biochemistry Renal function Urine urologic and male genital diseases chemistry.chemical_compound Folic Acid Internal medicine Alpha-Globulins Blood plasma medicine Albuminuria Humans Renal Insufficiency Dialysis Aged Creatinine Albumin General Medicine Middle Aged Endocrinology chemistry Pyridoxal Phosphate Regression Analysis Female Iohexol Glomerular Filtration Rate medicine.drug |
| Zdroj: | Scandinavian Journal of Clinical and Laboratory Investigation. 56:41-46 |
| ISSN: | 1502-7686 0036-5513 |
| DOI: | 10.3109/00365519609088586 |
| Popis: | The concentration of homocysteine in plasma has been shown to be increased in renal failure, possibly contributing to the accelerated atherosclerosis observed in uraemic patients. The aim of the present study was to document the relationship between plasma total homocysteine (tHcy) concentrations and glomerular filtration rates (GFR) in highly selected patients, with renal function ranging from normal to dialysis dependency. GFR was defined as the plasma clearance of iohexol; a more accurate method than the creatinine-based estimations applied in previous studies. Plasma tHcy concentrations were highly correlated to GFR (r = -0.70, p < 0.0001) and were significantly increased already in moderate renal failure. According to a multiple regression analysis, GFR and red cell folate concentrations independently predicted plasma tHcy concentrations, whereas those of serum creatinine, plasma pyridoxal-5-phosphate, urine albumin and urine alpha-1-microglobulin (a marker of tubular damage) did not. Thus, GFR seems to be a better determinant of plasma tHcy concentration than serum creatinine concentration. Plasma total cysteine and total cysteinylglycine concentrations followed the same pattern as those of tHcy. |
| Databáze: | OpenAIRE |
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