Development of a multiple-unit system: Tablets containing amlodipine besylate which have different release kinetics
| Autor: | Gizem Tilki, Timuçin Uğurlu, Ozan Tekdemir |
|---|---|
| Přispěvatelé: | Tekdemir, Ozan, Tilki, Gizem, Ugurlu, Timucin |
| Rok vydání: | 2020 |
| Předmět: |
ORALLY DISINTEGRATING TABLETS
PHARMACOKINETICS Chromatography sodium starch glycolate DISSOLUTION ENHANCEMENT Chemistry Kinetics extended release tablet Multiple unit system hydroxyl propyl cellulose crospovidon medicine Multi unit Amlodipine immediate release tablet amlodipine besylate fluctuation of plasma drug concentration medicine.drug |
| Zdroj: | Journal of Research in Pharmacy. 24:572-581 |
| ISSN: | 2630-6344 |
| DOI: | 10.35333/jrp.2020.205 |
| Popis: | Multiple-unit systems may include tablets, capsules, pellets in a single administration. Once-a-day administration of Amlodipine Besylate (AML) accounts for fluctuation of plasma drug concentrations between dosing intervals. The aim of this study is to develop an extended-release (ER) and an immediate-release (IR) tablet to overcome the fluctuation of plasma drug concentrations. To achieve this purpose, 9 IR tablets and 6 ER tablet formulations were developed. The dissolution media for IR tablets was pH 2 for 1 hour and the dissolution media for ER tablets was pH 2 for 2 hours, and afterwards was pH 6.8 for 10 hours. The amount of AML released into the dissolution media was measured by Mettler Toledo UV 5 at a wavelength of 238 nm. The dissolution data of IR and ER tablets were statically evaluated. The highest dissolution rate for IR tablets (93%) was achieved with the IR-5 formulation. For ER tablets, a 50% drug release was achieved with the ER-1 and ER-4 formulation. The drug release kinetics of all ER tablets were calculated and subsequently the ER-1 formulation, which has Higuchi drug release kinetics, was chosen as the ER tablet. Lastly, a dissolution study of the selected formulations (IR-5 and ER-1) was conducted in the same vessel. After 12 hours of the dissolution study, drug release was found to be 79% +/- 0,92 (close to 75% which was targeted). Multiple-unit systems that have different tablet formulations in one administration could be used to enhance drug release kinetics that cannot be achieved with conventional tablets. |
| Databáze: | OpenAIRE |
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