Influenza Vaccine Effectiveness and Waning Effect in Hospitalized Older Adults. Valencia Region, Spain, 2018/2019 Season
| Autor: | Mario Carballido-Fernández, Javier Díez-Domingo, Germán Schwarz-Chavarri, Miguel Tortajada-Girbés, Joan Puig-Barberà, Joan Mollar-Maseres, Beatriz Mengual-Chuliá, Ainara Mira-Iglesias, Javier García-Rubio, F. Xavier López-Labrador |
|---|---|
| Přispěvatelé: | UCH. Departamento de Medicina y Cirugía, Producción Científica UCH 2021 |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Influenza vaccine Health Toxicology and Mutagenesis Gripe - Vacunación - Eficacia - 2018-2019 - España - Valencia (Comunidad Valenciana) lcsh:Medicine effectiveness Article 03 medical and health sciences 0302 clinical medicine Influenza A Virus H1N1 Subtype Influenza - Vaccination - Efectiveness - 2018-2019 - Spain - Valencia (Autonomous Community) Vaccines - Efectiveness - 2018-2019 - Spain - Valencia (Autonomous Community) Internal medicine vaccine Influenza Human Older people - Hospital care - 2018-2019 - Spain - Valencia (Autonomous Community) medicine Humans 030212 general & internal medicine Prospective Studies Prospective cohort study hospitalizations Ancianos - Cuidados hospitalarios - 2018-2019 - España - Valencia (Comunidad Autónoma) 030304 developmental biology Aged 0303 health sciences business.industry Vacunas - Eficacia - 2018-2019 - España - Valencia (Comunidad Autónoma) Influenza A Virus H3N2 Subtype Vaccination lcsh:R Public Health Environmental and Occupational Health Influenza a Confidence interval Hospitalization Influenza Vaccines Spain Case-Control Studies waning surveillance Seasons business influenza |
| Zdroj: | International Journal of Environmental Research and Public Health Volume 18 Issue 3 International Journal of Environmental Research and Public Health, Vol 18, Iss 1129, p 1129 (2021) CEU Repositorio Institucional Fundación Universitaria San Pablo CEU (FUSPCEU) |
| ISSN: | 1660-4601 |
| DOI: | 10.3390/ijerph18031129 |
| Popis: | Influenza vaccination is annually recommended for specific populations at risk, such as older adults. We estimated the 2018/2019 influenza vaccine effectiveness (IVE) overall, by influenza subtype, type of vaccine, and by time elapsed since vaccination among subjects 65 years old or over in a multicenter prospective study in the Valencia Hospital Surveillance Network for the Study of Influenza and other Respiratory Viruses (VAHNSI, Spain). Information about potential confounders was obtained from clinical registries and/or by interviewing patients and vaccination details were only ascertained by registries. A test-negative design was performed in order to estimate IVE. As a result, IVE was estimated at 46% (95% confidence interval (CI): (16%, 66%)), 41% (95% CI: (−34%, 74%)), and 45% (95% CI: (7%, 67%)) against overall influenza, A(H1N1)pdm09 and A(H3N2), respectively. An intra-seasonal not relevant waning effect was detected. The IVE for the adjuvanted vaccine in ≥75 years old was 45% (2%, 69%) and for the non-adjuvanted vaccine in 65–74 years old was 59% (−16%, 86%). Thus, our data revealed moderate vaccine effectiveness against influenza A(H3N2) and not significant against A(H1N1)pdm09. Significant protection was conferred by the adjuvanted vaccine to patients ≥75 years old. Moreover, an intra-seasonal not relevant waning effect was detected, and a not significant IVE decreasing trend was observed over time. |
| Databáze: | OpenAIRE |
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