New Variants of Squash Mosaic Viruses Detected in Human Fecal Samples
Autor: | Vanessa dos Santos Morais, Roberta Marcatti, Ester Cerdeira Sabino, Eric Delwart, Rafael Brustulin, Xutao Deng, Antonio Charlys da Costa, Fabiola Villanova, Élcio Leal, Flavio Augusto de Pádua Milagres, Mayara Bertanhe, Cassio Hamilton Abreu-Junior, Emerson Luiz Lima Araújo, Roozbeh Tahmasebi, Steven S. Witkin |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
Microbiology (medical)
Squash mosaic virus QH301-705.5 viruses medicine.disease_cause Microbiology 03 medical and health sciences Virology Plant virus Rotavirus medicine Human virome Biology (General) 030304 developmental biology next generation sequencing 0303 health sciences virome biology Mosaic virus 030306 microbiology Communication public health plant viruses Sapovirus biology.organism_classification Parechovirus Norovirus |
Zdroj: | Microorganisms Microorganisms, Vol 9, Iss 1349, p 1349 (2021) |
ISSN: | 2076-2607 |
Popis: | Squash mosaic virus (SqMV) is a phytovirus that infects great diversity of plants worldwide. In Brazil, the SqMV has been identified in the states of Ceará, Maranhão, Piauí, Rio Grande do Norte, and Tocantins. The presence of non-pathogenic viruses in animals, such as phytoviruses, may not be completely risk-free. Similarities in gene repertories between these viruses and viruses that affect animal species have been reported. The present study describes the fully sequenced genomes of SqMV found in human feces, collected in Tocantins, and analyzes the viral profile by metagenomics in the context of diarrhea symptomatology. The complete SqMV genome was obtained in 39 of 253 analyzed samples (15.5%); 97.4% of them belonged to children under 5 years old. There was no evidence that the observed symptoms were related to the presence of SqMV. Of the different virus species detected in these fecal samples, at least 4 (rotavirus, sapovirus, norovirus, parechovirus) are widely known to cause gastrointestinal symptoms. The presence of SqMV nucleic acid in fecal samples is likely due to recent dietary consumption and it is not evidence of viral replication in the human intestinal cells. Identifying the presence of SqMV in human feces and characterization of its genome is a relevant precursor to determining whether and how plant viruses interact with host cells or microorganisms in the human gastrointestinal tract. |
Databáze: | OpenAIRE |
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