Severe central nervous system damage and profound acidosis in persons exposed to pentaborane
| Autor: | M. H. Steele, K. R. Cooper, B. E. Yarbrough, D. I. Zolet, Lorne K. Garrettson, A. B. Kelleher |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Adult
Central Nervous System Male Spasm Time Factors Health Toxicology and Mutagenesis Partial Pressure Poison control Toxicology Respiratory compensation chemistry.chemical_compound Seizures Convulsion medicine Humans Boranes Acidosis business.industry Poisoning Metabolic acidosis Carbon Dioxide Hydrogen-Ion Concentration medicine.disease Pentaborane Occupational Diseases Oxygen chemistry Liver Anesthesia Toxicity Lactates medicine.symptom business Rhabdomyolysis |
| Zdroj: | Journal of toxicology. Clinical toxicology. 23(7-8) |
| ISSN: | 0731-3810 |
| Popis: | Three cases of pentaborane intoxication resulting from a common exposure are presented. These cases were characterized by the rapid onset of seizures and opisthotonic spasms accompanied by severe metabolic acidosis without respiratory compensation. Rhabdomyolysis occurred, serum transaminase levels were elevated, and liver damage was demonstrated histologically. One patient died and another sustained severe neurologic damage. These poisonings are unique with respect to the rapid and devastating neurologic consequences. Pentaborane is an extremely toxic compound and a major hazard not only to exposed workers but also to the medical personnel dealing with them. |
| Databáze: | OpenAIRE |
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