Identification of a High Risk Subgroup of Grade 1 Transitional Cell Carcinoma Using Image Analysis Based Deoxyribonucleic Acid Ploidy Analysis of Tumor Tissue
| Autor: | Robert E. Hurst, Jianyu Rao, Rebecca B. Bonner, Bobby G. Smith, Tommy Hewett, George P. Hemstreet, Philip Jones, Scott Rollins |
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| Rok vydání: | 1991 |
| Předmět: |
Pathology
medicine.medical_specialty Urology Aneuploidy Risk Factors Bladder Neoplasm Biopsy Image Processing Computer-Assisted Carcinoma Humans Medicine Survival analysis Retrospective Studies Carcinoma Transitional Cell Ploidies Bladder cancer medicine.diagnostic_test business.industry DNA Neoplasm Flow Cytometry Prognosis medicine.disease Transitional cell carcinoma Urinary Bladder Neoplasms Transitional Cell Neoplasm Recurrence Local business |
| Zdroj: | Journal of Urology. 146:1525-1529 |
| ISSN: | 1527-3792 0022-5347 |
| DOI: | 10.1016/s0022-5347(17)38157-0 |
| Popis: | The use of deoxyribonucleic acid (DNA) cytometry to identify a subset of patients with grade 1, stage Ta or T1 transitional cell carcinoma at high risk for death or recurrence was investigated in a retrospective study using paraffin blocks from 88 low grade transitional cell carcinomas of the bladder with an absorptiometric video-based image analysis system. Tumors were evaluated for ploidy (70 diploid, 16 aneuploid and 2 tetraploid) and the presence of cells with greater than 5C DNA. Survival analysis of 62 patients with adequate followup (15 to 20 years) showed that 43 of 62 (69%) suffered recurrences and 13 (21%) died of bladder cancer. The single most important predictors of death and recurrence were stem line aneuploidy and the presence of cells with greater than 5C DNA, respectively. |
| Databáze: | OpenAIRE |
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