In vivo visualization and analysis of 3-D hemodynamics in cerebral aneurysms with flow-sensitized 4-D MR imaging at 3T
Autor: | Aurélien F. Stalder, Stephan Meckel, Stephan G. Wetzel, Michael Markl, Francesco Santini, Daniel A. Rüfenacht, Ernst W. Radü |
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Jazyk: | angličtina |
Rok vydání: | 2018 |
Předmět: |
medicine.medical_specialty
Hemodynamics Magnetic resonance angiography Aneurysm Imaging Three-Dimensional In vivo medicine Humans Radiology Nuclear Medicine and imaging cardiovascular diseases Neuroradiology medicine.diagnostic_test business.industry Reproducibility of Results Intracranial Aneurysm Blood flow Middle Aged medicine.disease Mr imaging Cerebrovascular Circulation Cerebral Angiography cardiovascular system Feasibility Studies Female Vascular Resistance Neurology (clinical) Radiology Cardiology and Cardiovascular Medicine Nuclear medicine business Blood Flow Velocity Magnetic Resonance Angiography |
Popis: | Introduction: Blood-flow patterns and wall shear stress (WSS) are considered to play a major role in the development and rupture of cerebral aneurysms. These hemodynamic aspects have been extensively studied in vitro using geometric realistic aneurysm models. The purpose of this study was to evaluate the feasibility of in vivo flow-sensitized 4-D MR imaging for analysis of intraaneurysmal hemodynamics. Methods: Five cerebral aneurysms were examined using ECG-gated, flow-sensitized 4-D MR imaging at 3T in three patients. Postprocessing included quantification of flow velocities, visualization of time-resolved 2-D vector graphs and 3-D particle traces, vortical flow analysis, and estimation of WSS. Flow patterns were analyzed in relation to aneurysm geometry and aspect ratio. Results: Magnitude, spatial and temporal evolution of vortical flow differed markedly among the aneurysms. Particularly unstable vortical flow was demonstrated in a wide-necked parophthalmic ICA aneurysm (high aspect ratio). Relatively stable vortical flow was observed in aneurysms with a lower aspect ratio. Except for a wide-necked cavernous ICA aneurysm (low aspect ratio), WSS was reduced in all aneurysms and showed a high spatial variation. Conclusion: In vivo flow-sensitized 4-D MR imaging can be applied to analyze complex patterns of intraaneurysmal flow. Flow patterns, distribution of flow velocities, and WSS seem to be determined by the vascular geometry of the aneurysm. Temporal and spatial averaging effects are drawbacks of the MR-based analysis of flow patterns as well as the estimation of WSS, particularly in small aneurysms. Further studies are needed to establish a direct link between definitive flow patterns and different aneurysm geometries |
Databáze: | OpenAIRE |
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