Obesity Induced by Neonatal Monosodium Glutamate Treatment in Spontaneously Hypertensive Rats: An Animal Model of Multiple Risk Factors
| Autor: | Mototaka Yoshinari, Misao Yamamoto, Kenzo Iino, Masatoshi Fujishima, Noriyasu Shinohara, Masanori Iwase, Kojiro Ichikawa |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
medicine.medical_specialty
Arteriosclerosis Physiology Hyperlipidemias Diabetes Mellitus Experimental Impaired glucose tolerance Insulin resistance Risk Factors Hyperinsulinism Rats Inbred SHR Diabetes mellitus Internal medicine Sodium Glutamate Hyperlipidemia Internal Medicine medicine Hyperinsulinemia Animals Obesity cardiovascular diseases Aorta Glycated Hemoglobin Hypertriglyceridemia business.industry DNA musculoskeletal system medicine.disease Rats Disease Models Animal Carotid Arteries Cholesterol Endocrinology Animals Newborn Diabetes Mellitus Type 2 Hypertension cardiovascular system Female Food Additives Metabolic syndrome Tunica Intima Cardiology and Cardiovascular Medicine business circulatory and respiratory physiology |
| Zdroj: | Hypertension Research. 21:1-6 |
| ISSN: | 1348-4214 0916-9636 |
| DOI: | 10.1291/hypres.21.1 |
| Popis: | The present study was designed to develop an animal model of multiple risk factors, including obesity, hypertension, non-insulin-dependent diabetes mellitus, and hyperlipidemia. Hypothalamic obesity was induced by neonatal monosodium glutamate (MSG) treatment in spontaneously hypertensive rats (SHR). Female newborn SHR were treated intraperitoneally with 2 or 4 mg/kg body weight of MSG for 5 days. Obesity developed in SHR treated with 4 mg/kg of MSG but not in SHR treated with 2 mg/kg of MSG. Obese SHR had impaired glucose tolerance, hyperinsulinemia, and hypertriglyceridemia. However, the severity of hypertension was attenuated in obese SHR as compared with control SHR. The degree of obesity was closely related to the metabolic abnormalities, but inversely correlated with the blood pressure level. Macrovascular changes were investigated in obese SHR at 14 months of age. Intimal thickening was accelerated in the carotid artery of obese SHR as compared with that of nonobese SHR. Aortic contents of DNA and total cholesterol were significantly increased in obese SHR. SHR associated with MSG-induced obesity showed major manifestations of metabolic syndrome X. This animal model may be useful to study the clustering of risk factors for the development of macrovascular diseases. |
| Databáze: | OpenAIRE |
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