Use of bisphosphonates in a retrospective case series of children and adolescents with complex regional pain syndrome

Autor:	Michelle Stoopler, Nada Mohamed, Víctor Hugo González Cárdenas, Y Laura Nathaly Ricaurte Gracia, Gonzalo Rivera, Anne Marie Sbrocchi, Pablo Ingelmo, Laurel Walfish
Rok vydání:	2021
Předmět:	Male Pediatrics medicine.medical_specialty Physical disability Adolescent medicine.medical_treatment Physical function medicine Clinical endpoint Humans Adverse effect Child Infusions Intravenous Retrospective Studies Diphosphonates business.industry Chronic pain Bisphosphonate medicine.disease Anesthesiology and Pain Medicine Zoledronic acid Complex regional pain syndrome Pediatrics Perinatology and Child Health Injections Intravenous Female business Complex Regional Pain Syndromes medicine.drug
Zdroj:	Paediatric anaesthesiaREFERENCES. 31(8)
ISSN:	1460-9592
Popis:	Background There is increasing evidence for the use of bisphosphonates to treat Complex Regional Pain Syndrome in adults. However, there is scarce data for their use in children with Complex Regional Pain Syndrome. Aim This retrospective case series aimed to analyze the effects of intravenous bisphosphonate use in children and adolescents with Complex Regional Pain Syndrome enrolled in a multidimensional pain treatment program. Methods We analyzed the data of 16 patients (15 females and 1 male, mean age 14±3 years) who received infusions of Zoledronic acid (0.015±0.0044mg/kg), Pamidronate (0.72±0.17mg/kg) or both depending on their initial response between October 2014 and December 2019. The primary endpoint of the study was the patient's global impression of change. Secondary outcomes included pain intensity, physical function, role function (school attendance), need for pain medications, and adverse effects. Results Nine of 16 patients reported meaningful improvements (global impressions of change of 84% or higher) at a median follow-up time of 16 (8-21) months after their last infusion of bisphosphonates. There were also meaningful reductions in pain intensity and the need for pain medications. There was an increase in the proportion of patients with minimal or without physical disability, and almost all patients normalized their school activities. Thirteen patients (81%) reported adverse effects, mostly flu-like symptoms, for a few days after the infusion. Conclusion The use of bisphosphonate infusions may represent an effective treatment option for children with Complex Regional Pain Syndrome, not responding to multidisciplinary pain treatment programs.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56dc79ebd7267396968b3b333dfdc406 https://pubmed.ncbi.nlm.nih.gov/33999470 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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