Exploring Cognitive Concomitants of Mental Fatigue in Patients with Coronary Artery Disease
| Autor: | David Wellsted, Narseta Mickuvienė, Adomas Bunevicius, Naomi A. Fineberg, Julius Burkauskas, Julija Brožaitienė, Julius Neverauskas, Robertas Bunevičius |
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| Rok vydání: | 2018 |
| Předmět: |
Psychomotor learning
Mini–Mental State Examination medicine.diagnostic_test business.industry 05 social sciences Trail Making Test Cognition Hospital Anxiety and Depression Scale Mental health 03 medical and health sciences Psychiatry and Mental health 0302 clinical medicine Neuropsychology and Physiological Psychology Memory span medicine Anxiety 0501 psychology and cognitive sciences 030212 general & internal medicine 050102 behavioral science & comparative psychology medicine.symptom business Biological Psychiatry Clinical psychology |
| Zdroj: | Neuropsychobiology. 76(3) |
| ISSN: | 1423-0224 |
| Popis: | Objective: Fatigue and reduced exercise capacity are common concomitants of coronary artery disease (CAD). They are known to be associated with the deterioration in mental health, including emotional and cognitive status. However, the precise nature of the inter-relationship is poorly understood. The aim of this study was to investigate the relationship between fatigue and exercise capacity on the one hand and changes in cognitive functioning on the other, to generate new heuristics for clinical management and outcome prediction of CAD. Methods: A cross-sectional study included 827 in-patients (58 ± 9 years, 75% men) with CAD. Patients were evaluated for demographic, cardiac characteristics, and exercise capacity. The Multidimensional Fatigue Inventory-20 was used to assess fatigue, the Mini Mental State Examination for global cognitive function, the Digit Span Test, Digit Symbol Test, and Trail Making Test for executive aspects of cognitive functioning, and the Hospital Anxiety and Depression Scale for anxiety and depression symptom severity. Results: Using multiple regression analysis, after adjusting for possible confounders such as anxiety and depression, mental fatigue was associated with several executive aspects of cognitive function including short-term memory (Digit Symbol Test pairs recalled correctly [β = –0.127, p < 0.005]), psychomotor performance (time to complete the Digit Symbol Test [β = 0.089, p < 0.03]), and cognitive processing speed (Trail Making Test A [β = 0.081, p < 0.05]). Conclusion: In rehabilitating CAD patients, certain aspects of executive functioning were independently associated with mental fatigue. These findings suggest that the subjective experience of mental fatigue, rather than reduced exercise capacity, is significantly associated with cognitive function. |
| Databáze: | OpenAIRE |
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