RESEARCH ADVANCES IN NEUROBLASTOMA IMMUNOTHERAPY
| Autor: | Titilope A. Ishola, Dai H. Chung, Kanika A. Bowen, Latania Y. Booker |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Oncology
medicine.medical_specialty biology business.industry medicine.medical_treatment Multimodal therapy Immunotherapy medicine.disease Pediatric cancer Article Immune system Antigen Radioimmunotherapy Internal medicine Neuroblastoma Pediatrics Perinatology and Child Health Immunology medicine biology.protein Antibody business |
| Zdroj: | Current pediatric reviews. 5(2) |
| ISSN: | 1875-6336 |
| Popis: | Neuroblastoma is the third most common pediatric cancer in the United States and is responsible for 15% of pediatric cancer-related deaths. Despite major advances in multimodal therapy, the clinical outcome for several patients remains poor. Due to the desperate need for innovativation and improved success in the treatment and management of neuroblastoma, research interests in immunotherapy have been on the rise in recent years. Current immunotherapeutic approaches under investigation include antibodies targeting the neuroblastoma antigen GD2, cytokine stimulation of immune cells, use of immunocytokine conjugates, radioimmunotherapy, and tumor-primed dendritic cells. Immunotherapy could serve as a safe alternative or adjunct to current therapeutic protocols and would presumptively have fewer deleterious effects making it more favorable to patients. |
| Databáze: | OpenAIRE |
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