Oxidative Modification of Proteins: From Damage to Catalysis, Signaling, and Beyond
| Autor: | Lía M. Randall, Ohara Augusto, Renata N. Bicev, Fernando Ribeiro Gomes, Luis Eduardo Soares Netto, Fernanda Marques da Cunha, Etelvino J. H. Bechara, Marilene Demasi, Sayuri Miyamoto, Fernanda M. Cerqueira, Cassius V. Stevani, Leonor Thomson, Ana Denicola |
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| Přispěvatelé: | Demasi Marilene, Instituto Butantán (Brasil), Augusto Ohara, Universidade de São Paulo (Brasil), Bechara Etelvino J.H., Universidade de São Paulo (Brasil), Bicev Renata N., Universidade de São Paulo (Brasil), Cerqueira Fernanda M., Instituto Butantán (Brasil), da Cunha Fernanda M., Universidade Federal de São Paulo (Brasil), Denicola Ana, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Química Biológica., Gomes Fernando, Universidade de São Paulo (Brasil), Miyamoto Sayuri, Universidade de São Paulo (Brasil), Netto Luis E.S., Universidade de São Paulo (Brasil), Randall Carlevaro Lía Margarita, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Química Biológica., Stevani Cassius V., Universidade de São Paulo (Brasil), Thomson Leonor, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Química Biológica. |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Physiology Clinical Biochemistry Oxidative phosphorylation Protein oxidation Biochemistry Catalysis 03 medical and health sciences chemistry.chemical_compound Humans Redox biology OXIDAÇÃO Molecular Biology Reactive nitrogen species General Environmental Science chemistry.chemical_classification Reactive oxygen species 030102 biochemistry & molecular biology Proteins Cell Biology 030104 developmental biology Proteostasis chemistry General Earth and Planetary Sciences Reactive Oxygen Species Oxidation-Reduction Signal Transduction |
| Zdroj: | COLIBRI Universidad de la República instacron:Universidad de la República Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 1557-7716 1523-0864 |
| Popis: | Significance: The systematic investigation of oxidative modification of proteins by reactive oxygen species started in 1980. Later, it was shown that reactive nitrogen species could also modify proteins. Some protein oxidative modifications promote loss of protein function, cleavage or aggregation, and some result in proteo-toxicity and cellular homeostasis disruption. Recent Advances: Previously, protein oxidation was associated exclusively to damage. However, not all oxidative modifications are necessarily associated with damage, as with Met and Cys protein residue oxidation. In these cases, redox state changes can alter protein structure, catalytic function, and signaling processes in response to metabolic and/or environmental alterations. This review aims to integrate the present knowledge on redox modifications of proteins with their fate and role in redox signaling and human pathological conditions. Critical Issues: It is hypothesized that protein oxidation participates in the development and progression of many pathological conditions. However, no quantitative data have been correlated with specific oxidized proteins or the progression or severity of pathological conditions. Hence, the comprehension of the mechanisms underlying these modifications, their importance in human pathologies, and the fate of the modified proteins is of clinical relevance. Future Directions: We discuss new tools to cope with protein oxidation and suggest new approaches for integrating knowledge about protein oxidation and redox processes with human pathophysiological conditions. |
| Databáze: | OpenAIRE |
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