Safety of 0.5% hydrogen peroxide mist used in the disinfection gateway for COVID-19
| Autor: | Vijayan Sangeetha, Sheela Bhasi Varsha, Unnikrishnan Vandana, Krishnan Jithin, Arumugham Sabareeswaran, Parayanthala Valappil Mohanan, Vayalappil Muraleedharan |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Coronavirus disease 2019 (COVID-19) Health Toxicology and Mutagenesis Disinfectant NOEL Physiology medicine.disease_cause Gross examination chemistry.chemical_compound Animals Humans Environmental Chemistry Medicine Rats Wistar Hydrogen peroxide Inhalation SARS-CoV-2 business.industry Skin irritation Mist COVID-19 Hydrogen Peroxide General Medicine Pollution Rats Disinfection chemistry Toxicity Inhalation toxicity Female Rabbits Irritation business Research Article |
| Zdroj: | Environmental Science and Pollution Research International |
| DOI: | 10.21203/rs.3.rs-421231/v1 |
| Popis: | Hydrogen peroxide (H2O2) is a reactive chemical used in a wide range of applications. Most importantly, it is used for sterilization process in health care environment. In the present study, safety assessment of 0.5% of H2O2or its mist intended to be used in the disinfection gateway for Covid-19 was evaluated. Skin irritation and repeated dose inhalation toxicity studies were carried out in rabbits and rats respectively. Skin irritation study revealed no observable oedema and erythema in rabbits after tropical application of 0.5% H2O2. Wistar rats (both male and female) were exposed (whole body exposure) to0.5% of H2O2 mist, at a concentration of 11.022 (low dose-2 min exposure), 22.044 (medium dose-4 min exposure) and 55.11mg/kg (high dose/high doe recovery-10 min exposure) body weight, daily for seven days. Rats in the high dose recovery group (55.11mg/kg-10 min exposure) were kept for another 7 days without any exposure. A toxicological evaluation was done based on general health parameters, haematology, serum biochemistry, gross necropsy and histopathological data. The results of the study indicated that there was no skin irritation potential induced on exposure of 0.5% of H2O2to rabbits. Similarly, the inhalation toxicity of 0.5% of H2O2 mist, imparts no evidence of haematological, biochemical, gross pathology or histopathological abnormalities in rats. Further, at the laboratory condition stimulated, the NOEL was found to be 55.11mg/kg body weight. Hence, the present study concluded that 0.5% H2O2 or its mist used in the disinfection gateway for COVID-19, failed to induce any skin irritation in rabbits or inhalation toxicity in rats. |
| Databáze: | OpenAIRE |
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