Author Correction: A Small Compound Targeting Prohibitin with Potential Interest for Cognitive Deficit Rescue in Aging mice and Tau Pathology Treatment
| Autor: | Yann Herault, Gwenaëlle Le Roux, Amie K. Lund, Serena Pavoni, Laurent Meijer, Anne-Cécile Guyot, Narciso Costa, Aloïse Mabondzo, Clémence Disdier, Nassima Oumata, Paloma F. Varela, Charlotte Leuxe, Jean-Baptiste Charbonnier, Emile Andriambeloson, Hervé Galons, Arnaud Duchon, Stéphanie Wagner |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Aging Tau pathology Neurogenesis Interleukin-1beta Drug Evaluation Preclinical MEDLINE lcsh:Medicine Mice Transgenic Nerve Tissue Proteins tau Proteins Bioinformatics Hippocampus Mice Text mining Prohibitins Animals Medicine Donepezil Molecular Targeted Therapy Phosphorylation Prohibitin Author Correction Maze Learning lcsh:Science Cells Cultured Cognitive deficit Glycogen Synthase Kinase 3 beta Neuronal Plasticity Multidisciplinary business.industry lcsh:R Brain Endothelial Cells Mitochondria Mice Inbred C57BL Repressor Proteins Neuroprotective Agents Gene Expression Regulation Tauopathies Blood-Brain Barrier lcsh:Q medicine.symptom Cognition Disorders business Neuroglia Protein Processing Post-Translational |
| Zdroj: | Scientific Reports, Vol 10, Iss 1, Pp 1-1 (2020) Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-020-67127-x |
| Popis: | Neurodegenerative diseases, including Alzheimer's and Parkinson's disease, are characterized by increased protein aggregation in the brain, progressive neuronal loss, increased inflammation, and neurogenesis impairment. We analyzed the effects of a new purine derivative drug, PDD005, in attenuating mechanisms involved in the pathogenesis of neurodegenerative diseases, using both in vivo and in vitro models. We show that PDD005 is distributed to the brain and can rescue cognitive deficits associated with aging in mice. Treatment with PDD005 prevents impairment of neurogenesis by increasing sex-determining region Y-box 2, nestin, and also enhances synaptic function through upregulation of synaptophysin and postsynaptic density protein 95. PDD005 treatment also reduced neuro-inflammation by decreasing interleukin-1β expression, activation of astrocytes, and microglia. We identified prohibitin as a potential target in mediating the therapeutic effects of PDD005 for the treatment of cognitive deficit in aging mice. Additionally, in the current study, glycogen synthase kinase appears to attenuate tau pathology. |
| Databáze: | OpenAIRE |
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