The influence of oxidative stress on cardiac remodeling in obese adolescents
Autor: | Gordana Milosevski-Lomic, Amira Peco-Antic, Aleksandra Vukašinović, Tamara Ilisic, Jelena Kotur-Stevuljevic, Dusan Paripovic |
---|---|
Rok vydání: | 2019 |
Předmět: |
Adult
Blood Glucose obesity medicine.medical_specialty hypertension Ambulatory blood pressure Adolescent Clinical Biochemistry Disease 030204 cardiovascular system & hematology Left ventricular hypertrophy medicine.disease_cause 03 medical and health sciences 0302 clinical medicine Internal medicine medicine oxidative stress Humans Insulin 030212 general & internal medicine Obesity Child 2. Zero hunger Ventricular Remodeling business.industry General Medicine medicine.disease Lipid Metabolism Lipids left ventricular hypertrophy 3. Good health Oxidative Stress Cardiovascular Diseases Ambulatory Hypertension Cardiology Ambulatory blood pressure monitoring business Oxidative stress Biomarkers |
Zdroj: | Scandinavian Journal of Clinical and Laboratory Investigation |
ISSN: | 1502-7686 |
Popis: | Oxidative stress seems to be an important link between obesity and cardiovascular disease. The aim of our study was to assess oxidative stress in obese patients stratified according to ambulatory blood pressure status and to determine independent predictors of abnormal left ventricular geometry.A cross-sectional study was conducted. A total of 113 obese participants referred for 24-h ambulatory blood pressure monitoring (ABPM) aged 9-19 years, and 29 healthy controls were enrolled. In addition to anthropometric and biochemical measurements, such as fasting serum levels of glucose, insulin, lipid profile, and oxidative biomarkers, ABPM and echocardiography were performed.According to ABPM results, obese subjects were split in two groups: 57 hypertensive and 56 normotensive. Both hypertensive and normotensive obese participants had higher levels of oxidative stress parameters (pro-oxidative/antioxidative balance and total oxidant status) compared with control group. Levels of superoxide anion (O-2(-)) and sulfhydryl groups were higher in obese hypertensive participants as compared to obese normotensive and control groups. Abnormal left ventricular geometry among obese participants was independently associated with O-2(-) (p = .006) and body mass index z score (p = .020), with no significant impact of gender, while age and systolic blood pressure exhibited interaction term for the outcome.The independent effect of oxidative mechanisms on left ventricular geometry appears to start in childhood. Oxidative stress occurs in obese adolescents prior to the development of sustained hypertension. |
Databáze: | OpenAIRE |
Externí odkaz: |