Stroke related mortality at different altitudes: A 17-year nationwide population-based analysis from Ecuador
| Autor: | Simone Cordovez, Jorge E. Vasconez, Katherine Simbaña-Rivera, Alfredo Borrero, Marco Coral-Almeida, Alejandra Barreto-Grimales, Patricio S Espinosa, Aquiles R. Henriquez-Trujillo, Ginés Viscor, Paul Roderick, Esteban Ortiz-Prado, Lenin Gómez-Barreno |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Physiology Population Protective factor adaptation Lower risk angiogenesis Altitude Equador Physiology (medical) Epidemiology high altitude medicine Mortalitat QP1-981 Mortality education Stroke Neovascularization Original Research education.field_of_study business.industry Mortality rate Influència de l'altitud Effects of high altitude on humans medicine.disease Influence of altitude stroke mortality Angiogènesi Ecuador business Demography |
| Zdroj: | Dipòsit Digital de la UB Universidad de Barcelona Frontiers in Physiology Frontiers in Physiology, Vol 12 (2021) |
| Popis: | Introduction: Worldwide, more than 5.7% of the population reside above 1,500 m of elevation. It has been hypothesized that acute short-term hypoxia exposure could increase the risk of developing a stroke. Studies assessing the effect of altitude on stroke have provided conflicting results, some analyses suggest that long-term chronic exposure could be associated with reduced mortality and lower stroke incidence rates.Methods: An ecological analysis of all stroke hospital admissions, mortality rates, and disability-adjusted life years in Ecuador was performed from 2001 to 2017. The cases and population at risk were categorized in low (Results: A total of 38,201 deaths and 75,893 stroke-related hospital admissions were reported. High altitude populations (HAP) had lower stroke mortality in men [OR: 0.91 (0.88–0.95)] and women [OR: 0.83 (0.79–0.86)]. In addition, HAP had a significant lower risk of getting admitted to the hospital when compared with the low altitude group in men [OR: 0.55 (CI 95% 0.54–0.56)] and women [OR: 0.65 (CI 95% 0.64–0.66)].Conclusion: This is the first epidemiological study that aims to elucidate the association between stroke and altitude using four different elevation ranges. Our findings suggest that living at higher elevations offers a reduction or the risk of dying due to stroke as well as a reduction in the probability of being admitted to the hospital. Nevertheless, this protective factor has a stronger effect between 2,000 and 3,500 m. |
| Databáze: | OpenAIRE |
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