Autor: |
Ferhat Meziani, Eduardo Anglés-Cano, Philippe Chafey, Cédric Broussard, Madeleine Riès-Kautt, Julie Helms, Florence Toti, Dayana Barbosa da Cruz, Pascale Gaussem, Lluvia Ramírez Aquino, Laure Stiel, Lucas Cougourdan |
Rok vydání: |
2019 |
Předmět: |
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Zdroj: |
The FASEB Journal. 33:14270-14280 |
ISSN: |
1530-6860 0892-6638 |
Popis: |
Activation of platelets and neutrophils in septic shock results in the formation of microvascular clots containing an intricate scaffold of fibrin with neutrophil extracellular traps (NETs) DNA. NETs contain multiple components that might impact endogenous fibrinolysis, resulting in failure to lyse clots in the microcirculation and residual systemic microthrombosis. We propose herein that the reservoir of human neutrophil elastase (HNE) on NETs may directly interfere with the fibrinolytic mechanism |
Databáze: |
OpenAIRE |
Externí odkaz: |
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