DNA‐bound elastase of neutrophil extracellular traps degrades plasminogen, reduces plasmin formation, and decreases fibrinolysis: proof of concept in septic shock plasma

Autor:	Ferhat Meziani, Eduardo Anglés-Cano, Philippe Chafey, Cédric Broussard, Madeleine Riès-Kautt, Julie Helms, Florence Toti, Dayana Barbosa da Cruz, Pascale Gaussem, Lluvia Ramírez Aquino, Laure Stiel, Lucas Cougourdan
Rok vydání:	2019
Předmět:	0301 basic medicine Plasmin medicine.medical_treatment Extracellular Traps Biochemistry Fibrin 03 medical and health sciences 0302 clinical medicine Fibrinolysis Genetics medicine Humans Platelet Fibrinolysin Molecular Biology Aged Aged 80 and over Disseminated intravascular coagulation Pancreatic Elastase biology Chemistry Septic shock Elastase Plasminogen Neutrophil extracellular traps Disseminated Intravascular Coagulation Middle Aged medicine.disease Shock Septic Cell biology 030104 developmental biology Case-Control Studies biology.protein 030217 neurology & neurosurgery Biotechnology medicine.drug
Zdroj:	The FASEB Journal. 33:14270-14280
ISSN:	1530-6860 0892-6638
Popis:	Activation of platelets and neutrophils in septic shock results in the formation of microvascular clots containing an intricate scaffold of fibrin with neutrophil extracellular traps (NETs) DNA. NETs contain multiple components that might impact endogenous fibrinolysis, resulting in failure to lyse clots in the microcirculation and residual systemic microthrombosis. We propose herein that the reservoir of human neutrophil elastase (HNE) on NETs may directly interfere with the fibrinolytic mechanism
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56cdd64bf8f26a32e19f2a9066b6fa01 https://doi.org/10.1096/fj.201901363rrr Zobrazit plný text záznamu Plný text